STUDY OF ACID REFLUX AND ASTHMA (SARA TRIAL)

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。哮喘和胃食管反流病（GERD）是常见的疾病，通常是非致命性的，但发病率和医疗费用很高。美国约4%-7%的人患有哮喘，约7%-20%的美国成年人每天都会出现反流症状。哮喘与反流胃食管反流同时存在的几率远高于偶然性。胃反流症状，虽然通常是轻微的，但在高达65-77%的哮喘患者中发生。通常，哮喘患者的反流也“沉默”，没有典型的症状，如胃灼热。反流反流在哮喘控制不佳的哮喘患者中尤为常见，并可引起支气管收缩。控制不佳的哮喘患者通常用抑制胃酸的药物来治疗胃反流，但这种治疗很昂贵，而且这种治疗的益处还没有确定。本研究的目的是进行一项多地点随机临床试验，以验证质子泵抑制剂治疗胃食管反流可以减少哮喘控制不充分患者发作频率的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma and Gastroesophageal Reflux Disease (GERD) are common disorders, usually non-lethal, but with high morbidity and healthcare costs. Asthma occurs in about 4%-7% of the US population, and GERD symptoms occur daily in approximately 7%-20% of US adults. The co-existence of asthma and GERD is far more frequent than chance association. GERD symptoms, although usually mild, occur in up to 65-77% of asthmatics. Often, GERD is "silent" in asthmatics as well, lacking typical symptoms such as heartburn. GERD is particularly frequent in asthmatics with poor asthma control and can induce bronchoconstriction. Poorly controlled asthmatics are often treated for GERD with drugs that suppress gastric acid, but this treatment is expensive and the benefit of such treatment is not established. The objective of this study is to conduct a multi-site randomized clinical trial testing the hypothesis that treatment of GERD with proton-pump inhibitors will reduce the frequency of exacerbations in patients with inadequately controlled asthma.