STUDY OF ACID REFLUX AND ASTHMA (SARA TRIAL)

胃酸反流和哮喘的研究（SARA 试验）

• 批准号: 7376870
• 负责人: Lewis J Smith
• 金额: $ 0.51万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376870
• 关键词: STUDY; ACID; REFLUX; ASTHMA; SARA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma and Gastroesophageal Reflux Disease (GERD) are common disorders, usually non-lethal, but with high morbidity and healthcare costs. Asthma occurs in about 4%-7% of the US population, and GERD symptoms occur daily in approximately 7%-20% of US adults. The co-existence of asthma and GERD is far more frequent than chance association. GERD symptoms, although usually mild, occur in up to 65-77% of asthmatics. Often, GERD is "silent" in asthmatics as well, lacking typical symptoms such as heartburn. GERD is particularly frequent in asthmatics with poor asthma control and can induce bronchoconstriction. Poorly controlled asthmatics are often treated for GERD with drugs that suppress gastric acid, but this treatment is expensive and the benefit of such treatment is not established. The objective of this study is to conduct a multi-site randomized clinical trial testing the hypothesis that treatment of GERD with proton-pump inhibitors will reduce the frequency of exacerbations in patients with inadequately controlled asthma.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。哮喘和胃食管反流病 (GERD) 是常见疾病，通常不致命，但发病率和医疗费用较高。大约 4%-7% 的美国人口患有哮喘，大约 7%-20% 的美国成年人每天都会出现 GERD 症状。哮喘和 GERD 共存的频率远高于偶然关联的频率。 GERD 症状虽然通常很轻微，但高达 65-77% 的哮喘患者会出现这种症状。通常，胃食管反流病在哮喘患者中也是“沉默的”，缺乏胃灼热等典型症状。 GERD 在哮喘控制不佳的哮喘患者中尤其常见，并可引起支气管收缩。控制不佳的哮喘患者通常使用抑制胃酸的药物来治疗胃食管反流病，但这种治疗费用昂贵，而且这种治疗的益处尚未确定。本研究的目的是进行一项多中心随机临床试验，测试以下假设：使用质子泵抑制剂治疗 GERD 将降低哮喘控制不充分的患者病情恶化的频率。