STUDY OF ACID REFLUX AND ASTHMA (SARA TRIAL)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 哮喘和胃食管反流病（GERD）是常见的疾病，通常是非致命的，但具有高发病率和医疗保健费用。 哮喘发生在大约4%-7%的美国人口中，并且GERD症状每天发生在大约7%-20%的美国成年人中。 哮喘和GERD的共存远比偶然关联更频繁。 GERD症状，虽然通常是轻微的，发生在高达65-77%的哮喘患者。 通常，GERD在哮喘患者中也是“沉默的”，缺乏典型的症状，如胃灼热。 GERD在哮喘控制不佳的哮喘患者中特别常见，并可诱导支气管收缩。 控制不佳的哮喘患者通常用抑制胃酸的药物治疗GERD，但这种治疗费用昂贵，而且这种治疗的益处尚未确定。 本研究的目的是进行一项多中心随机临床试验，检验质子泵抑制剂治疗GERD将降低哮喘控制不佳患者的急性发作频率的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma and Gastroesophageal Reflux Disease (GERD) are common disorders, usually non-lethal, but with high morbidity and healthcare costs. Asthma occurs in about 4%-7% of the US population, and GERD symptoms occur daily in approximately 7%-20% of US adults. The co-existence of asthma and GERD is far more frequent than chance association. GERD symptoms, although usually mild, occur in up to 65-77% of asthmatics. Often, GERD is "silent" in asthmatics as well, lacking typical symptoms such as heartburn. GERD is particularly frequent in asthmatics with poor asthma control and can induce bronchoconstriction. Poorly controlled asthmatics are often treated for GERD with drugs that suppress gastric acid but this treatment is expensive and the benefit of such treatment is not established. The objective of this study is to conduct a multi-site randomized clinical trial testing the hypothesis that treatment of GERD with proton-pump inhibitors will reduce the frequency of exacerbations in patients with inadequately controlled asthma.