DIETARY SUPPLEMENTATION WITH SOY ISOFLAVONES IN ASTHMA

膳食补充剂大豆异黄酮治疗哮喘

• 批准号: 7604313
• 负责人: Lewis J Smith
• 金额: $ 2.51万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604313
• 关键词: DIETARY; SUPPLEMENTATION; SOY; ISOFLAVONES; ASTHMA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An epidemiologic study of patients with asthma has shown that increased intake of soy isoflavones correlates with less severe asthma. In experimental animals, treatment with the soy isoflavone genistein reduces airways inflammation and hyperresponsiveness. In vitro studies performed by us have shows that genistein reduces release of inflammatory compounds by human blood eosinophils. The purpose of this pilot study is to determine whether dietary supplementation with soy isoflavones has effects in patients with asthma. Twenty patients with asthma will supplement their diet with a soy isoflavone capsule for four weeks. Before and after the supplementation period, we will measure lung function, exhaled nitric oxide (a marker for airway inflammation), collect exhaled breath condensate to measure levels of inflammatory mediators in the airways, and isolate peripheral blood esoinophils to assess the impact of soy isoflavones on their function. We hypothesize that dietary supplementation with soy isoflavones will reduce exhaled nitric oxide level, reduce the inflammatory mediators in the exhaled breath condensate, and reduce the ability of eosinophils to release inflammatory molecules. Identifying if these hypothesized effects of soy isoflavones exist in asthma will provide a justification for further clinical studies.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 一项对哮喘患者的流行病学研究表明，大豆异黄酮类摄入量的增加与较轻的哮喘相关。在实验动物中，用大豆异黄酮染料木素治疗可以减少呼吸道炎症和高反应性。我们进行的体外研究表明，金雀异黄素减少了人血嗜酸性粒细胞释放炎性化合物。这项先导性研究的目的是确定饮食中添加大豆异黄酮是否对哮喘患者有效。20名哮喘患者将在四周的饮食中补充大豆异黄酮胶囊。在补充期前后，我们将测量肺功能，呼出一氧化氮(呼吸道炎症的标志)，收集呼出的呼吸冷凝液以测量呼吸道中炎症介质的水平，并分离外周血嗜酸粒细胞以评估大豆异黄酮对其功能的影响。我们假设饮食中添加大豆异黄酮会降低呼出的一氧化氮水平，减少呼出的呼吸冷凝液中的炎症介质，并降低嗜酸性粒细胞释放炎症分子的能力。确定这些假设的大豆异黄酮类物质是否存在于哮喘中，将为进一步的临床研究提供依据。