HIGH RESOLUTION STRUCTURE OF BACTERIOPHAGE P2

噬菌体 P2 的高分辨率结构

• 批准号: 7369612
• 负责人: JOAN JOHNSON
• 金额: $ 2.52万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369612
• 关键词: RESOLUTION; STRUCTURE; BACTERIOPHAGE; P2

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bacteriophages, herpesviruses and other large dsDNA viruses contain molecular machines that pump DNA into preassembled procapsids, triggering maturation with an associated cascade of particle size change, release of packaging enzymes, binding of proteins for cell association and activation of the particles for infection. These events are associated with capsid pressures exceeding, by 10-fold, that of bottled champagne, and are detected by a protein switch that transduces a signal from inside to outside of the particle.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。噬菌体、疱疹病毒和其他大的dsDNA病毒含有分子机器，其将DNA泵入预组装的原衣壳中，引发成熟，伴随着相关的级联的颗粒大小变化、包装酶的释放、用于细胞缔合的蛋白质的结合和用于感染的颗粒的活化。这些事件与超过瓶装香槟10倍的衣壳压力有关，并通过将信号从颗粒内部转导到外部的蛋白质开关进行检测。