Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的优化
基本信息
- 批准号:7187707
- 负责人:
- 金额:$ 25.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-09-28 至 2011-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The US Surgeon General has reported that diseases of the craniofacial region are among the most common health problems affecting the general population. Among these maladies, devastating head and neck cancers (HNC) single-handedly impose a significant biomedical burden by accounting for 8000 deaths and over 40,000 new cases each year in the U.S. alone. Most of these patients will require multimodality treatment with surgery, radiation, and chemotherapy. Although radiotherapy has increased survival it also results in damage to adjacent normal tissues leading to significant morbidity. The corrosive impact of these radiation induced side effects can be unrelenting and their complex management is rarely remedial. Surgical treatment of HNC poses an ongoing challenge as it is complicated by the severely problematic wound healing issues consequent to adjuvant radiation therapy. Standard of care currently dictates mandibular reconstruction utilizing free tissue transfer, requiring the harvest of bone and tissue from other parts of the body (leg, rib, or arm). These large, involved, and complex operations entail extended hospitalizations and attendant complications often lead to delays in initiation of radiation and/or chemotherapy jeopardizing prognosis as well as quality of life. Advances in biotechnology and surgical instrumentation have afforded a unique opportunity for collaborative efforts combining knowledge from both basic and clinical investigation to conduct translational research. This translational research has the potential to transform head and neck cancer reconstruction by bringing novel and more effective therapeutic strategies into clinical settings. The utilization of Distraction Osteogenesis (DO) for tissue replacement after oncologic resection or as a reconstructive option for deformations secondary to irradiated bone could have immense potential therapeutic ramifications. DO, the creation of new bone by the gradual separation of two osteogenic fronts, generates an anatomical and functional replacement of deficient tissue from local substrate. Radiation drastically impairs bone healing, precluding the utilization of DO as a durable and predictable reconstructive method for HNC. The central hypothesis to be tested in this proposal is that the deleterious effects of radiation on bone formation can be mitigated to allow functional restoration and successful regeneration of the mandible. To test this hypothesis we will utilize a novel rodent model of DO to generate specific metrics of diminished bone quality within the regenerate of irradiated distracted mandibles. We will then employ a series of pharmacologic and tissue engineering strategies to assuage the adverse impact of radiation induced injury on new bone formation and healing in order to optimize reconstruction and repair. The long term goal of this proposal is to provide fundamental information that can be translated from the bench to the bedside to lead to improved treatment modalities to this severely compromised patient population.
描述(由申请人提供):美国外科医生报告称,颅面区域疾病是影响普通人群的最常见健康问题之一。在这些疾病中,仅在美国,毁灭性的头颈癌(HNC)就造成了重大的生物医学负担,每年造成8000人死亡和40,000多例新病例。这些患者中的大多数将需要手术,放疗和化疗的多模式治疗。虽然放射治疗提高了生存率,但它也会导致邻近正常组织的损伤,从而导致显著的发病率。这些辐射引起的副作用的腐蚀性影响可能是无情的,其复杂的管理很少是补救性的。HNC的手术治疗构成了持续的挑战,因为它被辅助放射治疗引起的严重问题性伤口愈合问题所复杂化。目前的护理标准规定利用游离组织移植进行下颌骨重建,需要从身体的其他部位(腿、肋骨或手臂)采集骨和组织。这些大型、复杂和复杂的手术需要延长住院时间和伴随的并发症,通常导致放疗和/或化疗的延迟,危及预后和生活质量。生物技术和手术器械的进步为合作提供了一个独特的机会,将基础和临床研究的知识结合起来进行转化研究。这项转化研究有可能通过将新的更有效的治疗策略引入临床环境来改变头颈癌重建。在肿瘤切除术后使用牵张成骨(DO)进行组织置换或作为继发于辐照骨的变形的重建选择,可能具有巨大的潜在治疗效果。DO是通过两个成骨前沿的逐渐分离产生新骨,从局部基质产生缺陷组织的解剖和功能替代。放射严重损害骨愈合,排除使用DO作为HNC的持久和可预测的重建方法。在这个提议中要测试的中心假设是,辐射对骨形成的有害影响可以减轻,以允许下颌骨的功能恢复和成功再生。为了检验这一假设,我们将利用一种新的啮齿动物模型的DO产生特定的指标,减少骨质量内再生的辐射牵引下颌骨。然后,我们将采用一系列的药理学和组织工程学策略,以减轻放射性损伤对新骨形成和愈合的不利影响,以优化重建和修复。该提案的长期目标是提供基本信息,这些信息可以从实验室转化为床旁信息,从而改善这一严重受损患者人群的治疗方式。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
STEVEN R BUCHMAN其他文献
STEVEN R BUCHMAN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('STEVEN R BUCHMAN', 18)}}的其他基金
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
8657300 - 财政年份:2013
- 资助金额:
$ 25.1万 - 项目类别:
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
8437308 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的优化
- 批准号:
8109343 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
8844020 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
9178698 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
8972002 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
9178639 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
9397821 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的优化
- 批准号:
7666080 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
8591378 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
相似国自然基金
骨病多模态报告和数据系统(Bone-RADS):规范精准风险评估并优化诊疗管理建议的临床研究
- 批准号:
- 批准年份:2024
- 资助金额:5.0 万元
- 项目类别:省市级项目
MFB(Main Fractured Bone)概念结合AO分型对桡骨远端骨折的临床诊疗研究
- 批准号:2018JJ4093
- 批准年份:2018
- 资助金额:0.0 万元
- 项目类别:省市级项目
骨形态发生蛋白(Bone Morphogenetic Proteins,BMP)信号在脊髓损伤中枢神经性疼痛中的作用
- 批准号:81070994
- 批准年份:2010
- 资助金额:32.0 万元
- 项目类别:面上项目
相似海外基金
Optimization of regeneration technique for bone and cartilage derived from iPS cells
iPS 细胞来源的骨和软骨再生技术的优化
- 批准号:
26293336 - 财政年份:2014
- 资助金额:
$ 25.1万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
8657300 - 财政年份:2013
- 资助金额:
$ 25.1万 - 项目类别:
Optimization of Regeneration Technique for Large Bone Defect
大骨缺损再生技术的优化
- 批准号:
23390364 - 财政年份:2011
- 资助金额:
$ 25.1万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Optimization of bone regeneration by use of mesenchymal stem cells and its application for closure of jaw cleft
间充质干细胞优化骨再生及其在颌裂闭合中的应用
- 批准号:
23593029 - 财政年份:2011
- 资助金额:
$ 25.1万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Optimization of the bone regeneration system using small molecules and examination of its molecular mechanisms
小分子骨再生系统优化及其分子机制研究
- 批准号:
23390460 - 财政年份:2011
- 资助金额:
$ 25.1万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
8437308 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的优化
- 批准号:
8109343 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
8844020 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
9178698 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别:
Translational Optimization of Bone Regeneration in the Irradiated Mandible
照射下颌骨骨再生的平移优化
- 批准号:
8972002 - 财政年份:2007
- 资助金额:
$ 25.1万 - 项目类别: