INFLAMMATORY PROFILES OF CHILDREN AT HIGH RISK FOR ATHEROSCLEROSIS

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Overall goal is to better understand the relationship between elevated levels of inflammatory markers in childhood and proven cardiovascular risk factors, by describing inflammatory makers and known cardiovascular risk factors in children with parents or grandparents who have premature atherosclerotic disease (cases) as defined by the National Cholesterol Education Program (NCEP)(1) and the American Academy of Pediatrics (AAP), (2) and controls without such a family history. Cases and controls will be further divided into groups with and without hyperlipidemia to allow clarification of interaction between hyperlipidemia and family history of early atherosclerosis.