From risk to resilience: understanding and altering profiles of multisystem stress physiology to protect children vulnerable to internalizing disorders

从风险到复原力：了解和改变多系统应激生理学特征，以保护易受内化障碍影响的儿童

• 批准号: 10368102
• 负责人: Danielle S. Roubinov
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10368102
• 关键词: Address; Adrenal Glands; Affect; Age; Area; Attention; Attenuated; Basic Science; Child; Child Mental Health; Child Welfare; Communities; Complex; Data; Depressed mood; Development; Developmental Process; Disease; Etiology; Exposure to; Family; Female; Gender; Goals; Hypothalamic structure; Individual; Intervention; Intervention Studies; Investigational Therapies; Joints; Life; Life Cycle Stages; Mediating; Mental Depression; Mental Health; Mentored Patient-Oriented Research Career Development Award; Modeling; Mood Disorders; National Institute of Mental Health; Outcome; Parasympathetic Nervous System; Parents; Pathway interactions; Pattern; Physiological; Physiological Processes; Physiology; Pilot Projects; Pituitary Gland; Prevention program; Process; Psychopathology; Regulation; Research; Research Personnel; Research Training; Risk; Risk Factors; Role; Sampling; Statistical Data Interpretation; Stress; Sympathetic Nervous System; Symptoms; System; Testing; Time; Training; Translational Research; Ursidae Family; Variant; biobehavior; biological adaptation to stress; cohort; depressive symptoms; early childhood; early life adversity; effective intervention; enhancing factor; experience; feasibility testing; foster care; gender difference; hypothalamic-pituitary-adrenal axis; improved; innovation; intervention effect; intervention program; novel; offspring; post intervention; programs; psychobiology; psychologic; resilience; statistics; stress reactivity; theories; therapy development; treatment effect; treatment program

PROJECT SUMMARY/ABSTRACT Internalizing disorders are among the most prevalent forms of psychopathology in early childhood with negative consequences that persist across the life course. Although parental depression heightens risk for children's internalizing problems, a significant proportion of at-risk offspring do not develop psychopathology. The factors that render children at risk or confer resilience in the context of parental depression remain poorly understood and in particular, scarce research has explored physiological moderators of the relations between parental depression and children's internalizing. Variations in children's integrated, multisystem stress physiology and parent-child physiological synchrony may distinguish children who are resilient from those who are adversely affected by parental depression. Moreover, stress-sensitive physiological pathways are a promising, but understudied target of treatments that can help elucidate the etiology of children's internalizing disorders and contribute to more effective interventions. This K23 Award builds upon the candidate's prior training and experience to fill critical gaps in the areas of developmental psychopathology and psychobiology, resilience, and intervention research. First, the candidate will examine the longitudinal, transactional relations between parental depressive symptoms and children's internalizing symptoms using in-depth data collected from two unique, extant longitudinal community samples of children that vary in age and exposure to risk. Second, the candidate will test children's multisystem stress reactivity as a moderator of these relations in the same two cohorts. Finally, the candidate will examine the feasibility of the Attachment and Biobehavioral Catch-up (ABC) intervention in a pilot sample of parent-child dyads with elevated depressive and internalizing symptoms, respectively, and assess the preliminary effects of ABC on children's multisystem physiology and parent-child physiological synchrony. Using the NIMH experimental therapeutics approach to intervention development, the candidate will test whether the ABC intervention improves regulation of these physiological factors as potential mechanisms by which to ultimately reduce children's internalizing symptoms. The ABC program is an empirically-supported biobehavioral intervention that is well-suited to attenuate patterns of physiological dysregulation that may underlie relations between parental depression and children's internalizing symptoms, but to date, it has only been delivered to children in foster care and the child welfare system. This novel pilot study will be the first to test the intervention among parents and children with elevated mental health symptoms and will explore its effects on a broader range of physiological outcomes. This research will advance understanding of the dynamic relations among parent depression, child and parent-child stress physiology, and child internalizing early in life, and will contribute to the development of innovative prevention and treatment programs. Through the proposed training and research, the candidate will contribute to cutting-edge research that promotes positive mental health outcomes among at-risk children and families.

项目总结/摘要 内化障碍是儿童早期最常见的精神病理学形式之一， 在整个生命过程中持续存在的负面后果。尽管父母的抑郁会增加 儿童的内化问题，一个风险的后代显着比例不发展精神病理学。 在父母抑郁的背景下，使儿童处于危险之中或赋予复原力的因素仍然很差 了解，特别是，稀缺的研究已经探讨了生理调节剂之间的关系， 父母抑郁与儿童内化。儿童综合性多系统压力的变化 生理学和亲子生理同步性可以区分具有弹性的儿童和 会受到父母抑郁症的不利影响此外，压力敏感的生理途径是一种 一个有前途的，但研究不足的治疗目标，可以帮助阐明儿童的内在病因， 疾病，并有助于更有效的干预措施。这个K23奖建立在候选人的先前 培训和经验，以填补发展精神病理学和精神生物学领域的关键空白， 恢复力和干预研究。首先，候选人将考察纵向的、交易性的关系 父母的抑郁症状和儿童的内化症状之间的关系， 从两个独特的，现存的纵向社区样本的儿童，不同的年龄和暴露于风险。 第二，候选人将测试儿童的多系统压力反应，作为这些关系的调节剂， 同样的两支队伍最后，候选人将检查附件和生物行为的可行性 在抑郁和内化水平升高的父母-子女二人组的试点样本中进行追赶（ABC）干预 症状，并评估ABC对儿童的多系统生理和 亲子生理同步使用NIMH实验治疗方法进行干预 发展，候选人将测试是否ABC干预改善这些生理调节 这些因素是最终减少儿童内化症状的潜在机制。美国广播公司 该计划是一种由药物支持的生物行为干预，非常适合于减弱 生理失调可能是父母抑郁症和儿童抑郁症之间关系的基础。 内化症状，但到目前为止，它只提供给寄养儿童和儿童福利 系统这项新的试点研究将是第一个在父母和儿童中测试干预措施的实验。 心理健康症状，并将探讨其对更广泛的生理结果的影响。这 研究将促进对父母抑郁、孩子和亲子之间动态关系的理解 压力生理学，和儿童内化早期生活，并将有助于发展创新 预防和治疗方案。通过拟议的培训和研究，候选人将作出贡献 到促进高危儿童和家庭积极心理健康结果的前沿研究。