INHALED NITRIC OXIDE FOR PEDIATRIC PAINFUL SICKLE CRISIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。主要目的：本II期临床试验的主要目的是评估吸入一氧化氮治疗镰状细胞病患儿急性血管闭塞性疼痛危像的临床疗效。本研究的主要结果测量是疼痛评分从基线到16小时的变化，将使用10cm视觉模拟量表（VAS）进行评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Objective: The primary goal of this proposed phase II clinical trial is to evaluate the clinical effectiveness of inhaled nitric oxide for the treatment of acute vaso-occlusive pain crisis in pediatric patients with sickle cell disease. The primary outcome measure for this study is change in pain score from baseline to 16 hours, which will be assessed using a 10cm visual analog scale (VAS).