INHALED NITRIC OXIDE FOR PEDIATRIC PAINFUL SICKLE CRISIS

吸入一氧化氮治疗小儿痛苦的镰状危机

• 批准号: 7380754
• 负责人: DEBRA KAYE WEINER
• 金额: $ 5.76万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380754
• 关键词: INHALED; NITRIC; OXIDE; PEDIATRIC; PAINFUL

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Objective: The primary goal of this proposed phase II clinical trial is to evaluate the clinical effectiveness of inhaled nitric oxide for the treatment of acute vaso-occlusive pain crisis in pediatric patients with sickle cell disease. The primary outcome measure for this study is change in pain score from baseline to 16 hours, which will be assessed using a 10cm visual analog scale (VAS).

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。主要目的：这项拟议的II期临床试验的主要目标是评估吸入一氧化氮治疗镰状细胞病儿科患者急性血管闭塞性疼痛危象的临床有效性。 本研究的主要结局指标是疼痛评分从基线到16小时的变化，将使用10厘米视觉模拟量表（VAS）进行评估。