INHALED NITRIC OXIDE FOR PEDIATRIC PAINFUL SICKLE CRISIS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。主要目的：这项拟议的II期临床试验的主要目的是评价吸入一氧化氮治疗儿童镰状细胞病患者急性血管闭塞性疼痛危象的临床疗效。这项研究的主要结果衡量标准是疼痛评分从基线到16小时的变化，这将使用10 cm视觉模拟评分(VAS)进行评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Objective: The primary goal of this proposed phase II clinical trial is to evaluate the clinical effectiveness of inhaled nitric oxide for the treatment of acute vaso-occlusive pain crisis in pediatric patients with sickle cell disease. The primary outcome measure for this study is change in pain score from baseline to 16 hours, which will be assessed using a 10cm visual analog scale (VAS).