OSTEOARTHRITIS INITIATIVE: A KNEE STUDY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。约有2070万美国人被医生诊断为骨关节炎，还有更多的人患有未诊断或亚临床疾病。目前评价骨性关节炎的技术是X线片。然而，这种方法对早期骨性关节炎的病理不敏感。需要其他成像方法和/或生物标志物，能够在放射学明显的阶段之前检测到骨性关节炎。这项多中心研究的目的是开发和评估新的、更敏感的技术来评估早期骨性关节炎，并评估可能作为早期骨关节病指标的骨性关节炎的潜在生物标志物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Approximately 20.7 million Americans have physician diagnosed osteoarthritis (OA), and many more have undiagnosed or subclinical disease. The present technique of OA evaluation is the radiograph. However, this method is insensitive to early OA pathology. Other imaging methods and/or biomarkers that capable of detecting OA prior to the stage when it becomes radiographically evident are needed. The purpose of this multicenter study is to develop and assess new, more sensitive technologies for assessing early stages of OA, and to evaluate potential biomarkers of OA that may be indicators of early osteoarthritic disease.