Treatments Against RA and Effect on FDG PET CT: The TARGET TRIAL

RA 治疗方法及 FDG PET CT 的影响:目标试验

基本信息

  • 批准号:
    9308669
  • 负责人:
  • 金额:
    $ 264.65万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-09-28 至 2021-11-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Rheumatoid arthritis (RA) is a chronic inflammatory disease causing joint damage and disability. While, remarkable progress in the treatment of RA over the past two decades has improved many outcomes, mortality rates in RA remain 1.5-3-fold above non-RA controls. Cardiovascular disease (CVD) is the leading cause of excess deaths in RA, and most experts believe that enhanced vascular inflammation underpins accelerated atherosclerosis and CV events. Yet, there has been no direct proof for this hypothesis. If true, then RA therapies that reduce joint inflammation might also reduce CV risk. The lack of an RA-specific CV risk tool hampers evidence-based guidelines, as general population tools perform poorly in RA. These gaps in knowledge create uncertainty for patients and providers in managing RA and its comorbidities. While an RCT with CV events as the outcome would be an ideal study approach to investigate the effect of RA treatments on CVD, there are notable barriers, including very large sample size requirement (~10,000), long trial duration (~3 years) requiring patients to maintain randomization, and the associated costs (~$60M). Moreover, many DMARDs raise LDL presenting ethical challenges in a CVD prevention trial, where enrolling high-risk patients would be desired. Therefore, an alternative outcome utilizing a surrogate CV measure that directly reflects vascular inflammation and has been demonstrated to be responsive to treatment (e.g., with statins) would serve as a scientifically important and feasible proof-of-concept trial. We propose here to use 18fluoro-deoxyglucose by positron emission tomography/computed tomography (FDG PET/CT) as a novel imaging modality to detect baseline, and DMARD-associated changes in, vascular inflammation in RA. We will compare the effects on FDG PET/CT of 2 treatment regimens in an RCT among methotrexate (MTX) inadequate responders, representing a critical and common decision point for rheumatologists and patients: addition of a TNFi vs sulfasalazine + hydroxychloroquine to background MTX (Aim 1). Recent RCTs show near equivalent reduction in articular disease activity, but the relative effects of these regimens on CV risk is unknown. Substantial basic science data as well as epidemiologic evidence support the superiority of TNFi on CV inflammation over non-biologic DMARDs, but this has never been studied in an RCT. Using data from the RCT, we will also compare the effects on vascular inflammation of achieving low disease activity or remission vs remaining in moderate-high disease activity. These pre-specified secondary analyses will pool the treatment arms to examine whether achievement of a disease activity target associates with greater reduction in vascular inflammation. Aim 2a will use DAS-28 scores to categorize treatment response and correlate it with vascular inflammation. Aim 2b will use a multi-biomarker of RA disease activity to categorize treatment response and correlate it with vascular inflammation. Aim 2c will use joint inflammation as measured by FDG PET/CT to categorize treatment response and correlate with vascular inflammation.
 描述(申请人提供):类风湿性关节炎(RA)是一种慢性炎症性疾病,会导致关节损伤和残疾。尽管过去二十年来类风湿性关节炎的治疗取得了显著进展,改善了许多结果,但类风湿性关节炎的死亡率仍然是非类风湿性关节炎对照组的1.5-3倍。心血管疾病(CVD)是RA患者过度死亡的主要原因,大多数专家认为,血管炎症加剧是加速动脉粥样硬化和心血管事件的基础。然而,目前还没有直接的证据支持这一假设。如果是真的,那么减少关节炎症的类风湿关节炎疗法也可能降低心血管风险。缺乏特定于RA的CV风险工具阻碍了基于证据的指南,因为一般的人口工具在RA中表现不佳。这些知识上的差距给患者和提供者在处理类风湿性关节炎及其并存方面带来了不确定性。虽然以心血管事件为结果的随机对照试验将是研究RA治疗对CVD影响的理想研究方法,但也存在明显的障碍,包括非常大的样本量要求(约10,000),试验持续时间长(~3年)要求患者保持随机化,以及相关成本(约6000万美元)。此外,许多DMARD提高了低密度脂蛋白,这在心血管疾病预防试验中提出了伦理挑战,在该试验中,希望招募高危患者。因此,使用直接反映血管炎症并已被证明对治疗(例如,使用他汀类药物)有反应的替代CV测量的替代结果将作为一项具有科学重要性和可行性的概念验证试验。我们建议使用18F-脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FDG PET/CT)作为一种新的成像手段来检测RA患者的基线和DMARD相关的血管炎症变化。我们将比较两种治疗方案在甲氨蝶呤(MTX)缺乏应答者的随机对照试验中对FDG PET/CT的影响,这代表了风湿科医生和患者的一个关键和共同的决策点:在背景MTX(目标1)中添加TNFi与柳氮磺胺吡啶+羟氯喹。最近的随机对照试验显示关节疾病活动度几乎相等地减少,但这些方案对心血管风险的相对影响尚不清楚。大量的基础科学数据和流行病学证据支持TNFi在治疗心血管炎症方面优于非生物DMARD,但这从未在随机对照试验中进行过研究。使用随机对照试验的数据,我们还将比较实现低疾病活动或缓解与保持中高疾病活动对血管炎症的影响。这些预先指定的二次分析将汇集治疗武器,以检查疾病活动目标的实现是否与更大程度地减少血管炎症有关。Aim 2a将使用DAS-28评分对治疗反应进行分类,并将其与血管炎症联系起来。目的2b将使用RA疾病活动性的多个生物标记物来分类治疗反应,并将其与血管炎症相关联。目的2c将使用FDGPET/CT测量的关节炎症来对治疗反应进行分类,并与血管炎症相关。

项目成果

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Joan Marie Bathon其他文献

Joan Marie Bathon的其他文献

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{{ truncateString('Joan Marie Bathon', 18)}}的其他基金

Multidisciplinary Training in Molecular and Translational Rheumatology Research
分子和转化风湿病研究的多学科培训
  • 批准号:
    10652991
  • 财政年份:
    2021
  • 资助金额:
    $ 264.65万
  • 项目类别:
Multidisciplinary Training in Molecular and Translational Rheumatology Research
分子和转化风湿病研究的多学科培训
  • 批准号:
    10441302
  • 财政年份:
    2021
  • 资助金额:
    $ 264.65万
  • 项目类别:
Multidisciplinary Training in Molecular and Translational Rheumatology Research
分子和转化风湿病研究的多学科培训
  • 批准号:
    10206896
  • 财政年份:
    2021
  • 资助金额:
    $ 264.65万
  • 项目类别:
Treatments Against RA and Effect on FDG PET CT: The TARGET TRIAL
RA 治疗方法及 FDG PET CT 的影响:目标试验
  • 批准号:
    9026031
  • 财政年份:
    2015
  • 资助金额:
    $ 264.65万
  • 项目类别:
Treatments Against RA and Effect on FDG PET CT: The TARGET TRIAL
RA 治疗及其对 FDG PET CT 的影响:目标试验
  • 批准号:
    9532568
  • 财政年份:
    2015
  • 资助金额:
    $ 264.65万
  • 项目类别:
Treatments Against RA and Effect on FDG PET CT: The TARGET TRIAL
RA 治疗方法及 FDG PET CT 的影响:目标试验
  • 批准号:
    9151628
  • 财政年份:
    2015
  • 资助金额:
    $ 264.65万
  • 项目类别:
Treat to Target to Reduce Atherosclerosis in Rheumatoid Arthritis
治疗以减少类风湿性关节炎的动脉粥样硬化为目标
  • 批准号:
    8641657
  • 财政年份:
    2013
  • 资助金额:
    $ 264.65万
  • 项目类别:
Treat to Target to Reduce Atherosclerosis in Rheumatoid Arthritis
治疗以减少类风湿性关节炎的动脉粥样硬化为目标
  • 批准号:
    8435756
  • 财政年份:
    2013
  • 资助金额:
    $ 264.65万
  • 项目类别:
ESCAPE - RA TRIAL
逃脱 - RA 审判
  • 批准号:
    7607472
  • 财政年份:
    2006
  • 资助金额:
    $ 264.65万
  • 项目类别:
OSTEOARTHRITIS INITIATIVE: A KNEE STUDY
骨关节炎倡议:膝关节研究
  • 批准号:
    7607468
  • 财政年份:
    2006
  • 资助金额:
    $ 264.65万
  • 项目类别:

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