OSTEOARTHRITIS INITIATIVE: A KNEE STUDY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Approximately 20.7 million Americans have physician diagnosed osteoarthritis (OA), and many more have undiagnosed or subclinical disease.The present technique of OA evaluation is the radiograph. However, this method is insensitive to early OA pathology. Other imaging methods and/or biomarkers that capable of detecting OA prior to the stage when it becomes radiographically evident are needed. The purpose of this multicenter study is to develop and assess new, more sensitive technologies for assessing early stages of OA, and to evaluate potential biomarkers of OA that may be indicators of early osteoarthritic disease.