NEUROBEHAVIORAL FEATURES & MESIAL TEMPORAL LOBE EPILEPSY

神经行为特征

• 批准号: 6889301
• 负责人: Bruce Phillip Hermann
• 金额: $ 38.22万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6889301
• 关键词: behavioral /social science research tag; cognition disorders; developmental neurobiology; developmental psychology; disease /disorder onset; disease /disorder proneness /risk; functional magnetic resonance imaging; human subject; magnetic resonance imaging; nervous system disorder epidemiology; neural degeneration; neuropathology; neuropsychological tests; partial seizure; patient oriented research; prognosis; temporal lobe /cortex disorder

We are proposing the first prospective investigation designed to detect progressive adverse effects of chronic early onset (less than age 14) temporal lobe epilepsy (TLE) on brain structure and function. This proposed study will combine high- resolution quantitative MRI volumetrics, comprehensive neuropsychological assessment, and an fMRI memory activation task. The purpose of this investigation is to test the hypothesis that early onset TLE is associated with a generalized adverse neurodevelopmental impact on both brain structure and function, an impact that may constitute an early-acquired neurobiological vulnerability for progressive cognitive decline in the face of ongoing chronic epilepsy. In this competing renewal application, we propose a longitudinal examination of 80 early onset TLE subjects and 80 age and gender matched controls that were initially seen for baseline testing four to five years earlier. All subjects will again undergo cognitive assessment and whole brain quantitative MRI volumetrics and a subset of subjects will undergo an fMRI object memory task. It is predicted that: 1) cognitive decline in this four-five year interval will be greater for early onset TLE subjects compared to controls, 2) decline will be most evident among those with longer duration of epilepsy, and for measures of memory function, speeded cognitive processing and non-verbal abilities compared to language based tasks, and 3) test-retest cognitive decline shown by early onset TLE subjects will be predicted by time total brain tissue volume and proportional brain tissue lost over the test- retest interval, and 4) increasing chronicity of epilepsy will be associated with decreasing mesial temporal lobe activation on an fMRI object memory task. Additional analyses will examine the impact of specific epilepsy course variables, depression, and associated chronic medical illness on longitudinal changes in TLE. The proposed study addresses an important and unresolved question concerning the possibility of progression in humans with TLE and the predictors of that decline. The findings will have potential implications for treatment as well as the understanding of the pathophysiology and natural history of TLE.

我们提出了第一项前瞻性研究，旨在检测慢性早发性(14岁以下)颞叶癫痫(TLE)对大脑结构和功能的渐进性不良影响。这项拟议的研究将结合高分辨率定量MRI体积测量、全面的神经心理学评估和功能磁共振记忆激活任务。本研究的目的是验证这一假说，即早发性TLE与对大脑结构和功能的全面不利神经发育影响有关，这种影响可能构成在持续慢性癫痫面前进行性认知能力下降的早期获得性神经生物学脆弱性。在这个相互竞争的更新应用中，我们建议对80名早发性TLE受试者和80名年龄和性别匹配的对照进行纵向检查，这些对照最初是在四到五年前进行基线测试的。所有受试者将再次接受认知评估和全脑定量MRI体积测量，一部分受试者将接受fMRI目标记忆任务。据预测：1)在这4-5年间，早发性TLE受试者的认知能力下降将比对照组更大，2)癫痫病程较长的受试者的认知能力下降将最为明显，记忆功能、认知加工和非语言能力的指标与基于语言的任务相比，3)早发性TLE受试者表现出的重测认知能力下降将通过重测期间脑组织总体积和脑组织丢失比例的时间来预测，4)癫痫慢性化程度的增加将与fMRI目标记忆任务中内侧颞叶激活的减少有关。其他分析将检查特定的癫痫病程变量、抑郁和相关的慢性内科疾病对TLE纵向变化的影响。这项拟议的研究解决了一个重要而悬而未决的问题，即人类TLE进展的可能性以及这种下降的预测因素。这一发现将对TLE的治疗以及对TLE的病理生理学和自然历史的理解具有潜在的意义。

项目成果

Cognitive phenotypes in childhood idiopathic epilepsies.

• DOI: 10.1016/j.yebeh.2016.05.013
• 发表时间: 2016-08
• 期刊: Epilepsy & behavior : E&B
• 作者: Hermann BP;Zhao Q;Jackson DC;Jones JE;Dabbs K;Almane D;Hsu DA;Stafstrom CE;Koehn MA;Seidenberg M;Rathouz PJ
• 通讯作者: Rathouz PJ

Mapping the neuropsychological profile of temporal lobe epilepsy using cognitive network topology and graph theory.

• DOI: 10.1016/j.yebeh.2016.07.030
• 发表时间: 2016-10
• 期刊: Epilepsy & behavior : E&B
• 作者: Kellermann TS;Bonilha L;Eskandari R;Garcia-Ramos C;Lin JJ;Hermann BP
• 通讯作者: Hermann BP

Co-morbid psychiatric disorder in chronic epilepsy: recognition and etiology of depression.

慢性癫痫的共病精神障碍：抑郁症的识别和病因学。

• 发表时间: 1999
• 期刊: Neurology.
• 作者: Wiegartz,P;Seidenberg,M;Woodard,A;Gidal,B;Hermann,B
• 通讯作者: Hermann,B

Brain structure and aging in chronic temporal lobe epilepsy.

• DOI: 10.1111/j.1528-1167.2012.03447.x
• 发表时间: 2012-06
• 期刊: Epilepsia
• 影响因子: 5.6
• 作者: Dabbs K;Becker T;Jones J;Rutecki P;Seidenberg M;Hermann B
• 通讯作者: Hermann B

Age-accelerated psychomotor slowing in temporal lobe epilepsy.

颞叶癫痫的年龄加速精神运动减慢。

• DOI: 10.1016/j.eplepsyres.2012.08.011
• 发表时间: 2013
• 期刊: Epilepsy research
• 影响因子: 2.2
• 作者: Sung,Connie;Jones,JanaE;Jackson,DarenC;Chan,YuiChung;Chan,Fong;Seidenberg,Michael;Hermann,BruceP
• 通讯作者: Hermann,BruceP