PROJECT ALLIFE - EXERCISE AND LEUKEMIA SURVIVORS

Project ALLIFE - 锻炼与白血病幸存者

• 批准号: 7377627
• 负责人: Mark J DeHaven
• 金额: $ 2.6万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377627
• 关键词: PROJECT; ALLIFE; EXERCISE; LEUKEMIA; SURVIVORS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adult survivors of childhood leukemia are a growing population that have an excess in all-cause and cardiovascular (CVD)-related mortality and are at risk for multiple health problems, including CVD, osteoporosis and obesity. Physical activity is protective and reduces risk for CVD, hypertension, type 2 diabetes mellitus, and osteoporosis. The Lifestyle Physical Activity intervention has been efficacious in the general population in increasing sustainable levels of moderate-intensity physical activity and cardiorespiratory fitness and improving cardiovascular risk profiles and mental health. A targeted intervention tailored to the needs of leukemia survivors and intended to increase sustainable levels of moderate-intensity physican activity is not only warranted, but critical. It is imperative that methods to reduce morbidity and mortality of this young population whil enhancing quality of life and productivity be addressed. This study, Project ALLIFE, is a 12-month effectiveness trial with 120 young adult survivors of childhood leukemia randomized to either the Lifestyle Physical Activity intervention (ALLIFE-1) or a standard control group who will receive a periodic generic health newsletter (ALLIFE-SC). The two primary outcomes to be measured will be levels of physical activity and cardiorespiratory fitness. Secondary outcomes will include other well-established measure of physical activity, cardiovascular risk profiles, gait and balance assessment, and psychological measurements. The primary research hypothesis to be tested is that the Lifestyle intervention will significantly increase physical activity and cardiorespiratory fitness in adult survivors of childhood leukemia in comparison with standard care. Three additional questions to be addressed are: determing if such an intervention leads to improvement in cardiovascular risk profile; determining if gait and balance disturbances are related to physical inactivity in leukemia survivors and if these disturbances improve with the intervention; and identifying factors that are predictive of improvement or lack of improvement in outcomes. This study will represent the first clinical trial aimed at increasing physical activity in leukemia survivors and will advance the understanding of this vulnerable population.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。儿童白血病的成年幸存者是一个不断增长的人群，他们的全因死亡率和心血管（CVD）相关死亡率过高，并面临多种健康问题的风险，包括心血管疾病、骨质疏松症和肥胖。体育活动具有保护作用，可降低心血管疾病、高血压、2型糖尿病和骨质疏松症的风险。在普通人群中，生活方式体育活动干预在提高中等强度体育活动和心肺健康的可持续水平以及改善心血管风险概况和心理健康方面是有效的。针对白血病幸存者的需要进行有针对性的干预，旨在提高中等强度体力活动的可持续水平，这不仅是必要的，而且是至关重要的。必须设法降低这一年轻人口的发病率和死亡率，同时提高生活质量和生产力。这项名为ALLIFE项目的研究是一项为期12个月的有效性试验，共有120名儿童白血病的年轻成年幸存者被随机分为生活方式体育活动干预组（ALLIFE-1）和标准对照组，后者将定期收到一份通用健康通讯（ALLIFE- sc）。要测量的两个主要结果将是身体活动水平和心肺健康。次要结果将包括其他完善的身体活动测量、心血管风险概况、步态和平衡评估以及心理测量。待验证的主要研究假设是，与标准治疗相比，生活方式干预将显著增加儿童白血病成年幸存者的身体活动和心肺健康。需要解决的另外三个问题是：确定这种干预是否会改善心血管风险概况；确定白血病幸存者的步态和平衡障碍是否与缺乏运动有关，以及这些障碍是否在干预后得到改善；并确定预测结果改善或缺乏改善的因素。这项研究将是第一个旨在增加白血病幸存者身体活动的临床试验，并将促进对这一弱势群体的了解。