Research Core

我们的综合研究核心和项目组成部分的目的是减少健康差距，这 对妇女、少数民族和低收入个人的影响不成比例。我们的项目和研究核心 各部分由基于社区的参与性研究(CBPR)的研究原则指导 和翻译研究。在本提案中，我们将把重点放在与妇女 健康差距，通过介绍三个对美国妇女非常重要的项目， 艾滋病毒/艾滋病、乳腺癌和肥胖： 项目一：皮涅狄格州阿努贾·戈帕德博士。健康差异和sCD40L：HIV-1疾病的新生物标志物 进步。该项目将研究可溶性CD40L水平作为艾滋病毒/艾滋病的预后生物标志物 种族和性别背景下的疾病进展。 项目2：J.K.Vishwanatha博士，Pi。三重阴性乳腺癌：新的生物标志物和治疗 战略。在这个项目中，Annexin A2的表达特征将与三重阴性的进化联系在一起 非裔美国女性中的乳腺癌。 项目3：马克·J·德黑文博士。通过生活方式减少非裔美国女性的肥胖 增强功能。该项目将评估一种减轻非裔美国女性体重的方法。 通过与非裔美国人会众的CBPR伙伴关系。 综合的具体目标是：1)开发综合的平台和结构，以解决 与妇女健康差距有关的重大健康问题；2)在以下领域开展高质量研究 妇女在艾滋病毒/艾滋病、乳腺癌和肥胖领域的健康差距将以一种方式减少 普遍存在的健康差距；3)为代表不足的少数族裔学生提供研究机会 (URM)和教职员工参与旨在消除妇女健康差距的有意义的研究， 通过研究核心和教育/培训核心之间的协作；4)加强以社区为基础 通过研究之间的合作参与妇女健康差距研究 核心和社区外展核心；以及，5)确定未来的生物标志物和/或风险因素 治疗途径，特别强调妇女的健康差距。

The purpose of our integrated research core and project components is to reduce health disparities, which disproportionately affect women, minorities, and low-income individuals. Our projects and research core components are guided by research principles derived from community-based participatory research (CBPR) and translational research. In the present proposal we will focus on problems related directly to women's health disparities, by presenting three projects of significant importance for women in the United States, HIV/AIDS, Breast Cancer, and Obesity: Project 1: Dr. Anuja Ghorpade, PI.' Health Disparities & sCD40L: Novel Biomarkers for HIV-1 Disease Progression. This project will study the levels of soluble CD40L as a prognostic biomarker for HIV/AIDS disease progression in the context of race and gender. Project 2: Dr. JK Vishwanatha, PI. Triple Negative Breast Cancer: Novel Biomarkers and Therapeutic Strategies. In this project the expression characteristics of Annexin A2 will be linked to the evolution of triplenegative breast cancer in African-American women. Project 3: Dr. Mark J. DeHaven, PI. Reducing Obesity in African American Women through Lifestyle Enhancement. This project will evaluate a means for reducing weight among African-American women through a CBPR partnership with African-American congregations. The integrated specific aims are to: 1) Develop an integrated platform and structure for addressing significant health problems related to Women's Health Disparities; 2) Perform high-quality research in Women's Health Disparities in the areas of HIV/AIDS, Breast Cancer, and Obesity in a way that will reduce prevalent health disparities; 3) Provide research opportunities for under-represented minority students (URM) and faculty to participate in meaningful research designed to eliminate Women's Health Disparities, through collaboration between the Research Core and the Education/Training Core; 4) Enhance communitybased participation in Women's Health Disparities research through collaboration between the Research Core and the Community Outreach Core; and, 5) Characterize biomarkers and/or risk factors for future therapeutic avenues with a specific emphasis on Women's Health Disparities.