The GOODNEWS (Genes, Nutrition, Exercise, Wellness, and Spiritual Growth) Trial

GOODNEWS（基因、营养、锻炼、健康和精神成长）试验

• 批准号: 7629668
• 负责人: Mark J DeHaven
• 金额: $ 47.55万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7629668
• 关键词: African American; American; Behavior; Blood Pressure; Body Weight decreased; Cardiovascular Diseases; Caring; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Data Collection; Diabetes Mellitus; Diet; Disease; Disease Management; Eating Behavior; Elements; Energy Metabolism; Exercise; Genes; Glucose; Goals; Growth; Guidelines; Health; Health Promotion; Health Services Accessibility; Health behavior change; Health education; Healthy People 2010; Heart Diseases; Hypertension; Individual; Intervention; Life Expectancy; Life Style; Lipoproteins; Low Income Population; Low income; Maintenance; Measures; Medical; Methodology; Methods; Minority; Minority Groups; Modeling; Nutritional; Outcome; Participant; Pharmaceutical Preparations; Physical activity; Population; Populations at Risk; Prevalence; Prevention strategy; Primary Prevention; Public Health; Questionnaires; Randomized; Recording of previous events; Research; Research Personnel; Research Technics; Resources; Risk; Risk Factors; Risk Reduction; Screening procedure; Socioeconomic Status; Stroke; System; Target Populations; Techniques; Testing; Time; Training; base; behavior change; cardiovascular disorder risk; cardiovascular risk factor; community based participatory research; discount; disorder prevention; effectiveness trial; evidence base; fasting glucose; group intervention; health disparity; high risk; improved; lifestyle intervention; low socioeconomic status; novel strategies; nutrition; prevent; primary outcome; programs; promoter; saturated fat; smoking cessation; success

DESCRIPTION (provided by applicant): Significant disparities in cardiovascular disease (CVD) risk factors, prevalence, and health outcomes persist among racial and ethnic minorities, and those with lower socioeconomic status (SES). Although Healthy People 2010 (HP) and national clinical guidelines endorse lifestyle change for preventing and reducing CVD prevalence, numerous barriers limit health behavior change in many minority and low-income communities. New risk reduction strategies are needed using community-based participatory research (CBPR) techniques, which allow researchers and communities to combine their efforts promoting health, preventing disease, and reducing health disparities. Collaborative strategies must move beyond investigating behavior change alone and begin focusing on behavior change maintenance. The GoodNEWS (Genes, Nutrition, Exercise, and Wellness and Spiritual Growth) Trial is an 18-month effectiveness trial with an 18-month extended maintenance study, among 20 African-American and low- income congregations participating in the GoodNEWS faith-based lay health promotion program. After training, congregations will be randomized to either GoodNEWS with a health maintenance intervention (GoodNEWS-l) or GoodNEWS program alone (GoodNEWS-PA). The maintenance intervention combines elements of the medical care model and features of community-based support. Primary data collection will occur at baseline, 18, and 36 months with the two primary outcomes being levels of physical activity as measured by 7- Day Physical Activity Recall (PAR) and dietary change as measured by the Diet History Questionnaire (DHQ). The primary hypothesis is that the maintenance group will significantly increase physical activity and healthy eating behavior compared to the program only group. We also hypothesize that lipoprotein and glucose levels, and blood pressure will be significantly improved over baseline in the GoodNEWS-l group and that these changes will be significantly greater than in the GoodNEWS-PA group. At the end of the trial, both groups will continue in an 18-month extended maintenance study. Relevance to Public Health: The GoodNEWS Trial is consistent with the Healthy People 2010 goal of eliminating health disparities. Lifestyle change is an important strategy for reducing CVD prevalence in high- risk populations. The proposed study will contribute to greater understanding of community-based health promotion and primary prevention strategies for reducing risk factors for heart disease and stroke in these populations, and maintaining lifestyle and behavior change over time.

描述（由申请人提供）：在种族和少数民族以及社会经济地位较低的人群中，心血管疾病（CVD）的危险因素、患病率和健康结果存在显著差异。尽管2010年健康人（HP）和国家临床指南支持改变生活方式以预防和减少心血管疾病的流行，但在许多少数民族和低收入社区，许多障碍限制了健康行为的改变。需要利用基于社区的参与性研究技术制定新的减少风险战略，使研究人员和社区能够将促进健康、预防疾病和缩小健康差距的努力结合起来。协作策略必须超越单独调查行为变化，并开始关注行为变化的维护。GoodNEWS（基因、营养、运动、健康和精神成长）试验是一项为期18个月的有效性试验，其中包括18个月的延长维持研究，在20个非裔美国人和低收入会众中参加了GoodNEWS以信仰为基础的健康促进计划。训练后，会众将被随机分配到有健康维护干预的GoodNEWS （GoodNEWS- 1）或单独的GoodNEWS计划（GoodNEWS- pa）。维持干预结合了医疗保健模式的要素和社区支持的特点。主要数据收集将在基线、18和36个月进行，两个主要结果是通过7天体力活动回忆（PAR）测量的体力活动水平和通过饮食史问卷（DHQ）测量的饮食变化。主要的假设是，与只进行计划的组相比，维持组会显著增加身体活动和健康饮食行为。我们还假设，在goodnews - 1组中，脂蛋白和血糖水平以及血压将比基线显著改善，并且这些变化将明显大于GoodNEWS-PA组。在试验结束时，两组将继续进行为期18个月的延长维持研究。与公共卫生相关：GoodNEWS试验与2010年健康人消除健康差距的目标是一致的。改变生活方式是降低高危人群心血管疾病患病率的重要策略。拟议的研究将有助于更好地了解以社区为基础的健康促进和初级预防策略，以减少这些人群中心脏病和中风的风险因素，并随着时间的推移保持生活方式和行为的改变。