NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。1型糖尿病（T1D）是一种由胰腺细胞破坏引起的疾病。它可以发生在任何年龄，但发病率最高的是儿童和青少年。虽然所有人都易受影响，但患有T1D的人的亲属患这种疾病的风险要大得多。本研究的总体目标是对T1D风险个体的代谢和免疫状态进行基线和长期重复评估，以表征其发展为T1D的风险，描述T1D的致病演变，并增加对T1D发展中涉及的致病因素的理解

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 1 diabetes (T1D) is a disease that results from the destruction of pancreatic beta cells. It can occur at any age, but its incidence is highest in children and adolescents. Although all people are susceptible, relatives of individuals with T1D are at a much greater risk for development of the disease. The overall objective of this study is to perform baseline and repeat assessments over time of the metabolic and immunologic status of individuals at risk for T1D in order to characterize their risk of developing T1D, to describe the pathogenic evolution of T1D, and to increase the understanding of the pathogenic factors involved in the development o