NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。1型糖尿病（T1 D）是一种由胰腺β细胞破坏引起的疾病。它可以发生在任何年龄，但其发病率最高的是儿童和青少年。虽然所有人都是易感的，但T1 D患者的亲属患该病的风险要大得多。 本研究的总体目标是对T1 D风险个体的代谢和免疫状态进行基线和重复评估，以描述其发生T1 D的风险，描述T1 D的致病演变，并增加对T1 D发生中涉及的致病因素的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 1 diabetes (T1D) is a disease that results from the destruction of pancreatic beta cells. It can occur at any age, but its incidence is highest in children and adolescents. Although all people are susceptible, relatives of individuals with T1D are at a much greater risk for development of the disease. The overall objective of this study is to perform baseline and repeat assessments over time of the metabolic and immunologic status of individuals at risk for T1D in order to characterize their risk of developing T1D, to describe the pathogenic evolution of T1D, and to increase the understanding of the pathogenic factors involved in the development o