NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。1型糖尿病(T1D)是一种由胰岛β细胞破坏引起的疾病。它可以发生在任何年龄，但它的发病率最高的是儿童和青少年。尽管所有人都是易感人群，但患有T1D的人的亲属患上这种疾病的风险要大得多。这项研究的总体目标是对T1D高危个体的代谢和免疫学状态进行基线和随时间的重复评估，以表征他们患T1D的风险，描述T1D的致病进化，并增加对T1D发生的致病因素的了解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 1 diabetes (T1D) is a disease that results from the destruction of pancreatic beta cells. It can occur at any age, but its incidence is highest in children and adolescents. Although all people are susceptible, relatives of individuals with T1D are at a much greater risk for development of the disease. The overall objective of this study is to perform baseline and repeat assessments over time of the metabolic and immunologic status of individuals at risk for T1D in order to characterize their risk of developing T1D, to describe the pathogenic evolution of T1D, and to increase the understanding of the pathogenic factors involved in the development o