ENERGY EXPENDITURE IN EARLY CHILDHOOD OF VERY LOW BIRTH WEIGHT INFANTS

极低出生体重婴儿幼儿期的能量消耗

• 批准号: 7379174
• 负责人: ANNA DUSICK
• 金额: $ 0.29万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379174
• 关键词: ENERGY; EXPENDITURE; EARLY; CHILDHOOD; VERY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Growth and physical development of the premature infant is a commonly used measure to assess general health status in infancy, and childhood. Most premature infants (>86%) are born with birth weights appropriate for their gestational age. However; achieving adequate growth in the neonatal intensive care unit is difficult. Most Very Low Birth Weight (VLBW birth weight < 1500g) infants are below usual and expected in utero growth rates near their term age equivalent or 40 weeks post-conceptional age. Therefore, at the time of discharge from the hospital (usually around "term age equivalent") the premature infant is already small for age. A significant number of these infants will fail-to-thrive through young childhood. SEveral factors have been identified that are related to poor growth outcome in the preterm infant and young child include: the lowest birth weight groups (< 1250g), preterm gestational age, severity of neonatal complications, poor neonatal head growth, chronic physical and neurological sequelae, Small-for Gestational Age birth weight. There is limited agreement as to the precise factors that increase the likelihood of catch-up growth after discharge from the nursery. Most likely, it is a multifactoral interaction between caloric and nutrient intake (diet and feeding ability of the infant), caloric need (total energy expenditure), and nutritional absorption and utilization for the infant in a catch-up phase of growth.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。早产儿的生长和身体发育是评估婴儿期和儿童期总体健康状况的常用指标。大多数早产儿（>86%）出生时体重与胎龄相符。然而，在新生儿重症监护室中实现适当的生长是困难的。大多数极低出生体重（VLBW出生体重<1500 g）婴儿在接近足月年龄或受孕后40周的子宫内生长速度低于正常和预期。 因此，在出院时（通常在“足月年龄”左右），早产儿已经很小了。这些婴儿中有相当多的人在幼儿期无法茁壮成长。已确定与早产儿和幼儿生长不良结局相关的几个因素包括：最低出生体重组（<1250 g）、早产胎龄、新生儿并发症的严重程度、新生儿头部生长不良、慢性身体和神经后遗症、小于胎龄出生体重。有有限的协议，确切的因素，增加了追赶增长的可能性后，从苗圃出院。最有可能的是，这是一个多因素之间的相互作用的热量和营养摄入（饮食和喂养能力的婴儿），热量需求（总能量消耗），营养吸收和利用的婴儿在追赶阶段的增长。