HIV-RELATED PROTEINURIA AND ENDOTHELIAL DYSFUNCTION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项前瞻性观察性研究将评估成人hiv感染者中蛋白尿与现有和进行性内皮功能障碍之间的关系。有蛋白尿和没有蛋白尿的受试者将在基线和24个月后进行臂血流介导的扩张和其他心血管危险因素的比较。共有72名受试者，36名持续性蛋白尿患者和36名非蛋白尿患者，预计将参加该研究，并随访约30个月。研究程序将包括生命体征测量、人体测量、尿液和血液测试以及肱动脉超声测量。受试者将被要求完成关于他们的锻炼活动和身体形象的调查问卷。参与者将被要求在每次超声测量前五天停止服用任何阿司匹林或类似阿司匹林的药物、糖尿病药物、高血压药物和高胆固醇药物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This prospective observational study will evaluate the associations between proteinuria and existing and progressive endothelial dysfunction in adult, HIV-infected individuals. Subjects with and without proteinuria will have their brachial-flow mediated dilation and other cardiovascular risk factors compared at baseline and again 24 months later. A total of 72 subjects, 36 subjects with persistent proteinuria and 36 non-proteinuric subjects, are expected to enroll in the study and be followed for approximately thirty months. Study procedures will include vital sign measurements, anthropometrics, urine and blood tests, and brachial artery ultrasound measurements. Subjects will be asked to complete questionnaires about their exercise activities and body image. Participants will be asked to stop taking any aspirin or aspirin like medications, diabetes medications, high blood pressure medications, and high cholesterol medications for five days before each of the ultrasound measurements.