HIV-RELATED PROTEINURIA AND ENDOTHELIAL DYSFUNCTION

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项前瞻性观察性研究将评估成人HIV感染者中蛋白尿与现有和进行性内皮功能障碍之间的关系。 有和无蛋白尿的受试者将在基线和24个月后再次比较他们的肱动脉血流介导的扩张和其他心血管危险因素。 预计共有72例受试者（36例持续性蛋白尿受试者和36例非蛋白尿受试者）入组研究，并接受约30个月的随访。 研究程序将包括生命体征测量、人体测量、尿液和血液检查以及肱动脉超声测量。 将要求受试者完成有关其锻炼活动和身体形象的问卷。 将要求参与者在每次超声测量前5天停止服用任何阿司匹林或阿司匹林类药物、糖尿病药物、高血压药物和高胆固醇药物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This prospective observational study will evaluate the associations between proteinuria and existing and progressive endothelial dysfunction in adult, HIV-infected individuals. Subjects with and without proteinuria will have their brachial-flow mediated dilation and other cardiovascular risk factors compared at baseline and again 24 months later. A total of 72 subjects, 36 subjects with persistent proteinuria and 36 non-proteinuric subjects, are expected to enroll in the study and be followed for approximately thirty months. Study procedures will include vital sign measurements, anthropometrics, urine and blood tests, and brachial artery ultrasound measurements. Subjects will be asked to complete questionnaires about their exercise activities and body image. Participants will be asked to stop taking any aspirin or aspirin like medications, diabetes medications, high blood pressure medications, and high cholesterol medications for five days before each of the ultrasound measurements.