NASOINTESTINAL TUBE STUDY IN YOUNG CHILDREN

幼儿鼻肠管研究

• 批准号: 7379154
• 负责人: MARSHA L ELLETT
• 金额: $ 0.02万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379154
• 关键词: NASOINTESTINAL; TUBE; STUDY; YOUNG; CHILDREN

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Feeding by nasointestinal (NI) tube is preferred for many children when the gastrointestinal system is functional, gastric feeding has been determined to be unsafe, and the need for assisted feeding is expected to be short-term. Regardless of the method used to place NI tubes, radiographs are routinely obtained to assure correct tube position prior to initiation of feedings. Subsequently, placement of NI tubes is not routinely checked. An NI tube's distal tip can shift upward from the duodenum into the stomach or even the esophagus, even when the external portion of the tube remains taped in place. This is especially likely when vomiting, severe coughing, or nasotracheal suctioning occurs. When tubes are out of place, children can be seriously harmed, causing increased morbidity. Increasing the safety of NI tube feeding in this population requires knowledge development in two areas-predicting the insertion distance for correct tube placement and maintaining correct tube positioning. This preliminary study is relevant to the second of these knowledge needs. The sample will consist of 50 hospitalized children < 19 years of age having an NI tube already in place. The pH and bilirubin levels of tube aspirate will be measured to detect gastric or intestinal location. Actual tube location will then be determined by abdominal radiograph to assess the adequacy of the placement-locating methods. The goal is to obtain initial estimates of prevalence of displacement, and sensitivity, specificity, positive and negative predictive value of the placement-locating methods to determine sample sizes needed in a future multi-center study. The long-term goal is to find the best clinical method(s) of determining the internal location of NI tubes in children.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。当胃肠系统功能正常，胃饲被确定为不安全，并且预计需要短期辅助喂养时，许多儿童首选鼻肠（NI）管喂养。无论使用何种方法放置NI管，均应常规拍摄X线片，以确保在开始喂食前正确放置管。随后，未对NI管的放置进行常规检查。NI管的远侧尖端可以从十二指肠向上移动到胃或甚至食道中，即使当管的外部部分保持用胶带固定在适当位置时。这在呕吐、剧烈咳嗽或鼻气管吸痰时尤其可能发生。当管子不合适时，儿童可能受到严重伤害，导致发病率增加。在这一人群中增加NI管喂养的安全性需要在两个方面进行知识开发-预测正确放置管的插入距离和保持正确的管定位。这一初步研究与第二种知识需求有关。 样本将包括50名年龄< 19岁的住院儿童，他们已经安装了NI管。将测量插管抽吸物的pH值和胆红素水平，以检测胃或肠位置。然后通过腹部X线片确定实际插管位置，以评估放置-定位方法的适当性。目的是获得位移患病率的初步估计值，以及放置定位方法的灵敏度、特异性、阳性和阴性预测值，以确定未来多中心研究所需的样本量。长期目标是找到确定儿童NI管内部位置的最佳临床方法。