Gastric Tube Placement in Young Children

描述（由申请人提供）：当胃肠系统功能正常且预计短期内需要辅助喂养时，首选鼻胃/口胃（NG/OG）管喂养。据估计，在美国，每年大约有100万成人和儿童植入肠内管。对儿童的初步研究表明，21%到44%的试管放置不正确。当管子放错位置时，儿童可能受到严重伤害，导致发病率增加，有时甚至死亡。儿童插管的研究尤其不足。在这一人群中，提高NG/OG喂养的安全性需要三个方面的知识发展：预测正确放置管的插入距离，确定管的位置，保持正确的管的位置。拟议的研究解决了前两个知识需求。目的是确定预测NG/OG管置入距离的最佳方法，确定NG/OG管置入后检测其位置的最佳临床方法。此外，由于CO2监测器之前没有经过充分的测试，因此本研究将提供有关该方法的关键初步信息。

DESCRIPTION (provided by applicant): Feeding by a nasogastric/orogastric (NG/OG) tube is preferred when the gastrointestinal system is functional and the need for assisted feeding is expected to be short-term. It is estimated that approximately one million enteral tubes are placed in adults and children in the United States annually. Preliminary studies in children show that between 21% and 44% of these tubes are placed incorrectly. When tubes are out of place, children can be seriously harmed, causing increased morbidity and occasionally death. Tube placement in children is especially understudied. Increasing the safety of NG/OG feeding in this population requires knowledge development in three areas---predicting the insertion distance for correct tube placement, determining tube position, and maintaining correct tube positioning. The proposed study addresses the first two of these knowledge needs. Goals are to determine the best method to predict the insertion distance for placing NG/OG tubes and to determine the best clinical methods of testing the location of NG/OG tubes once they are inserted. In addition, because the CO2 monitor has not been adequately tested previously, this study will provide critical preliminary information about this method. The sample will be 300 hospitalized children equal to or more than 100 months of age requiring gastric tubes. Subjects will have their tubes placed using one of three randomly assigned insertion-length predictors: age-related, height-based; nose-earxiphoid; or nose-ear midumbilicus. Immediately after insertion the position of the tube will be tested for unsuspected misplacement into the respiratory tree by measuring carbon dioxide (CO2) levels within the tube. Next pH and bilirubin levels of tube aspirate will be measured to detect gastric or intestinal location. Actual tube location will then be determined by abdominal radiograph to assess the adequacy of both the insertion length predictors and placement locating methods. Logistic regression will be used to compare the proportions of unsuspected misplacements among the insertion-length predictors and to compare the accuracies among the placement-locating methods. Results from this study will increase the safety of using gastric tubes in young children.