GENETICS OF BONE AND VASCULAR CALCIUM IN TYPE 2 DIABETES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项名为《2型糖尿病血管钙中骨的遗传学》的提案是美国国立卫生研究院资助的2型糖尿病亚临床心血管疾病遗传流行病学研究的辅助研究。主要研究的工作名称是糖尿病心脏研究(DHS)。在主要研究中，我们正在寻找可能导致心血管疾病的基因。2型糖尿病患者心脏病发作、中风和其他心血管疾病的风险非常高。先前的研究已经表明，血管钙化与骨骼中的钙之间存在关系，血管钙化是亚临床心血管疾病的一个指标。这项辅助研究增加了骨骼矿化的测量，以便我们能够寻找可能与这两种重要条件相互关联的遗传和环境原因。在这项研究中，先进的成像技术、分子遗传学和遗传流行病学技术都被用来寻找可能与这些疾病相关并可能共享的基因。这项辅助研究将提供支持NIH资金的数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal, Genetics of Bone in Vascular Calcium in Type 2 Diabetes is an ancillary study to the NIH funded study Genetic Epidemiology of Subclinical CVD in Type 2 Diabetes. The working name for the main study is the Diabetes Heart Study (DHS). In the main study we are searching for genes, which may be responsible for cardiovascular disease. Type 2 Diabetics are at very high risk for heart attack, stroke and other cardiovascular disease. Previous research has indicated a relationship between vascular calcifications, which are an indicator of subclinical CVD and calcium in the bones. This ancillary study adds measurements of skeletal mineralization so that we can look for genetic and environmental causes that may interrelate these two important conditions. In this study advanced imaging techniques, molecular genetics, and genetic epidemiologic techniques are all used to search for genes that may be responsible and potentially shared between these conditions. The ancillary study will provide the data to support NIH funding.