GENETICS OF BONE AND VASCULAR CALCIUM IN TYPE 2 DIABETES

2 型糖尿病中骨和血管钙的遗传学

• 批准号: 7607669
• 负责人: John Jeffrey Carr
• 金额: $ 2.12万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607669
• 关键词: Ancillary Study; Blood Vessels; Calcium; Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Diabetes Mellitus; Funding; Genes; Genetic; Grant; Heart; Imaging Techniques; Institution; Measurement; Molecular Genetics; Myocardial Infarction; Names; Non-Insulin-Dependent Diabetes Mellitus; Research; Research Personnel; Resources; Risk; Skeletal system; Source; Stroke; Techniques; United States National Institutes of Health; Vascular calcification; Work; bone; diabetic; genetic epidemiology; mineralization

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal, Genetics of Bone in Vascular Calcium in Type 2 Diabetes is an ancillary study to the NIH funded study Genetic Epidemiology of Subclinical CVD in Type 2 Diabetes. The working name for the main study is the Diabetes Heart Study (DHS). In the main study we are searching for genes, which may be responsible for cardiovascular disease. Type 2 Diabetics are at very high risk for heart attack, stroke and other cardiovascular disease. Previous research has indicated a relationship between vascular calcifications, which are an indicator of subclinical CVD and calcium in the bones. This ancillary study adds measurements of skeletal mineralization so that we can look for genetic and environmental causes that may interrelate these two important conditions. In this study advanced imaging techniques, molecular genetics, and genetic epidemiologic techniques are all used to search for genes that may be responsible and potentially shared between these conditions. The ancillary study will provide the data to support NIH funding.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项提案“2 型糖尿病中血管钙的骨遗传学”是 NIH 资助的研究“2 型糖尿病亚临床 CVD 遗传流行病学”的一项辅助研究。 主要研究的工作名称是糖尿病心脏研究 (DHS)。 在主要研究中，我们正在寻找可能导致心血管疾病的基因。 2 型糖尿病患者患心脏病、中风和其他心血管疾病的风险非常高。 先前的研究表明，血管钙化（亚临床心血管疾病的指标）与骨骼中的钙之间存在关系。 这项辅助研究增加了骨骼矿化的测量，以便我们可以寻找可能将这两个重要条件相互关联的遗传和环境原因。 在这项研究中，先进的成像技术、分子遗传学和遗传流行病学技术都被用来寻找可能与这些疾病有关并可能在这些疾病之间共享的基因。 辅助研究将提供数据来支持 NIH 的资助。