GENETICS OF BONE AND VASCULAR CALCIUM IN TYPE 2 DIABETES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal, Genetics of Bone in Vascular Calcium in Type 2 Diabetes is an ancillary study to the NIH funded study Genetic Epidemiology of Subclinical CVD in Type 2 Diabetes. The working name for the main study is the Diabetes Heart Study (DHS). In the main study we are searching for genes, which may be responsible for cardiovascular disease. Type 2 Diabetics are at very high risk for heart attack, stroke and other cardiovascular disease. Previous research has indicated a relationship between vascular calcifications, which are an indicator of subclinical CVD and calcium in the bones. This ancillary study adds measurements of skeletal mineralization so that we can look for genetic and environmental causes that may interrelate these two important conditions. In this study advanced imaging techniques, molecular genetics, and genetic epidemiologic techniques are all used to search for genes that may be responsible and potentially shared between these conditions. The ancillary study will provide the data to support NIH funding.