BIOIMAGING RESOURCE CORE

生物成像资源核心 (BIRC) 提供领导力、科学专业知识和仪器支持 定量成像技术，包括 MRI、CT、DXA 和 PET，对 WFU OAlC 的研究至关重要 主题：整合影响身体功能的途径，寻找残疾预防的新方法。的 BIRC与所有WFU OAIC核心良好集成，引领成像的开发和实现 量化和表征身体成分的技术和协议，特别是骨骼肌和 总的、区域的和器官特异性的脂肪组织，并获得血管和血管的非侵入性测量 神经肌肉功能。该核心还支持一个大型图像存储库，该存储库是在 当前周期，以促进对已建立成像的交叉研究比较和探索性分析 结果以及新成像表型的快速开发和验证。开发方法 在当前周期中已被证明在人类研究中具有稳健性和高精度 以及使用啮齿动物和非人类灵长类动物的转化模型。在本周期内，银保监会已 通过支持 3,431 幅图像采集（DXA、CT、MRI 和 PET）参与 10 项外部支持的研究、8 项试点研究和 3 项研究开发项目。 生物成像资源核心的具体目标是：1) 确定年龄和 骨骼肌和脂肪组织库中与疾病相关的变化，包括生物、遗传、共病、 心理社会和行为因素，以及与身体机能相关的其他结果； 2）衡量效果 对脂肪和骨骼的干预措施（饮食/营养、运动、药物和组合） 肌肉组织库； 3）使用体内生物成像来实现关键发现之间的双向转化 支持机械研究的人类和动物模型（包括非人类灵长类动物）； 4）开发 并验证新颖的非侵入性成像指标，以改善骨骼肌的表征， 老年人的脂肪组织和血管功能将与标准化的身体健康电池相结合 功能和实验室/分子评估。 银保监会领导团队由经验丰富、成功的调查人员组成，他们具有战略眼光 互补的技能组合以及协作科学和行政成就的良好记录。在 首年，银保监会将支持7个外部资助项目、2个试点项目和1个发展项目 项目。 BIRC 还将为 RCDC 支持的教师提供培训和指导，以培养以下方面的专业知识： 成像技术并促进他们作为独立转化研究科学家的发展。

The Biolmaging Resource Core (BIRC) provides leadership, scientific expertise and instrumental support in quantitative imaging techniques, including MRI, CT, DXA and PET, critical to the WFU OAlC's research theme: Integrating pathways affecting physical function for new approaches to disability prevention. The BIRC is well integrated with all WFU OAIC cores and leads the development and implementation of imaging techniques and protocols to quantify and characterize body composition, particularly skeletal muscle and total, regional and organ-specific adipose tissue and to obtain non-invasive measures of vascular and neuromuscular function. The Core also supports a large image repository that it developed during the present cycle in order to facilitate cross-study comparisons and exploratory analyses of established imaging outcomes as well as rapid development and validation of new imaging phenotypes. Methods developed during the current cycle have been demonstrated to be robust and of high precision in both human research and in translational models using rodents and nonhuman primates. During the present cycle, the BIRC has strongly contributed to the strong success of the OAIC by supporting 3,431 image acquisitions (DXA, CT, MRI and PET) in 10 externally-supported studies, 8 pilot studies and 3 research development projects. The specific aims of the Biolmaging Resource Core are to: 1) determine the associations of age and disease-related changes in skeletal muscle and adipose tissue depots with biological, genetic, co-morbid, psychosocial and behavioral factors, and other outcomes relevant to physical function; 2) measure the effects of interventions (dietary/nutritional, exercise, pharmacologic, and combinations) on adipose and skeletal muscle tissue depots; 3) use in vivo bio-imaging to enable bi-directional translation of key findings between humans and animal models (including nonhuman primates) in support of mechanistic research; 4) develop and validate novel non-invasive imaging metrics which allow improved characterization of skeletal muscle, adipose tissue and vascular function in older adults to be integrated with a standardized battery of physical function and laboratory/molecular assessments. The BIRC leadership team are highly experienced and successful investigators who have strategically complementary skill sets and strong records of collaborative scientific and administrative achievements. In the initial year, the BIRC will support 7 externally-funded projects, 2 pilot projects and 1 developmental project. The BIRC will also provide training and mentoring to RCDC-supported faculty to develop expertise in imaging techniques and to advance their development as independent translational research scientists.