BIOIMAGING RESOURCE CORE

生物成像资源核心

• 批准号: 7422515
• 负责人: John Jeffrey Carr
• 金额: $ 12.59万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7422515
• 关键词: Achievement; Adipose tissue; Affect; Age; Aging; Animal Disease Models; Animal Experimentation; Animal Model; Animals; Area; Basic Science; Behavioral; Biochemical; Biological; Blood Vessels; Blood flow; Body Composition; Body measure procedure; Characteristics; Clinical Trials; Cohort Studies; Data; Development; Direct Costs; Disease; Dual-Energy X-Ray Absorptiometry; Effectiveness of Interventions; Elderly; End Point; Etiology; Exercise; Faculty; Fatty acid glycerol esters; Funding; Generations; Genetic; Grant; Histologic; Human; Image; Imaging Device; Imaging Techniques; Individual; Infiltration; Inflammation; Intervention; Intervention Studies; Intramuscular; Invasive; Joints; Knowledge; Laboratories; Leadership; Link; Magnetic Resonance Imaging; Manuscripts; Measurement; Measures; Mentors; Methods; Metric; Mission; Modeling; Molecular; Muscle; Muscle function; Nutritional; Obesity; Organ; Outcome; Pathway interactions; Pericardial body location; Personal Satisfaction; Phenotype; Physical Function; Pilot Projects; Population; Positron-Emission Tomography; Prevention; Progress Reports; Protocols documentation; Protons; Purpose; Range; Records; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Resources; Rodent; Role; Science; Scientist; Serum Markers; Skeletal Muscle; Skeletal system; Slice; Support of Research; Techniques; Testing; Tissues; Training; Training and Education; Translating; Translational Research; Translations; Validation; Visceral; Work; age related; attenuation; base; bioimaging; density; design; disability; experience; functional decline; improved; in vivo; member; multidisciplinary; neuromuscular function; nonhuman primate; novel; novel strategies; psychosocial; repository; research and development; research study; response; skills; subcutaneous; success; tool

The Biolmaging Resource Core (BIRC) provides leadership, scientific expertise and instrumental support in quantitative imaging techniques, including MRI, CT, DXA and PET, critical to the WFU OAlC's research theme: Integrating pathways affecting physical function for new approaches to disability prevention. The BIRC is well integrated with all WFU OAIC cores and leads the development and implementation of imaging techniques and protocols to quantify and characterize body composition, particularly skeletal muscle and total, regional and organ-specific adipose tissue and to obtain non-invasive measures of vascular and neuromuscular function. The Core also supports a large image repository that it developed during the present cycle in order to facilitate cross-study comparisons and exploratory analyses of established imaging outcomes as well as rapid development and validation of new imaging phenotypes. Methods developed during the current cycle have been demonstrated to be robust and of high precision in both human research and in translational models using rodents and nonhuman primates. During the present cycle, the BIRC has strongly contributed to the strong success of the OAIC by supporting 3,431 image acquisitions (DXA, CT, MRI and PET) in 10 externally-supported studies, 8 pilot studies and 3 research development projects. The specific aims of the Biolmaging Resource Core are to: 1) determine the associations of age and disease-related changes in skeletal muscle and adipose tissue depots with biological, genetic, co-morbid, psychosocial and behavioral factors, and other outcomes relevant to physical function; 2) measure the effects of interventions (dietary/nutritional, exercise, pharmacologic, and combinations) on adipose and skeletal muscle tissue depots; 3) use in vivo bio-imaging to enable bi-directional translation of key findings between humans and animal models (including nonhuman primates) in support of mechanistic research; 4) develop and validate novel non-invasive imaging metrics which allow improved characterization of skeletal muscle, adipose tissue and vascular function in older adults to be integrated with a standardized battery of physical function and laboratory/molecular assessments. The BIRC leadership team are highly experienced and successful investigators who have strategically complementary skill sets and strong records of collaborative scientific and administrative achievements. In the initial year, the BIRC will support 7 externally-funded projects, 2 pilot projects and 1 developmental project. The BIRC will also provide training and mentoring to RCDC-supported faculty to develop expertise in imaging techniques and to advance their development as independent translational research scientists.

生物成像资源核心（BIRC）提供领导，科学专业知识和仪器支持 定量成像技术，包括MRI，CT，DXA和PET，对WFU OAlC的研究至关重要 主题：将影响身体功能的途径纳入预防残疾的新方法。的 BIRC与所有WFU OAIC内核集成良好，并引领成像的开发和实施 量化和表征身体成分的技术和方案，特别是骨骼肌， 总的、局部的和器官特异性的脂肪组织，并获得血管和 神经肌肉功能Core还支持一个大型图像存储库，该存储库是在 目前的周期，以促进交叉研究比较和探索性分析，建立成像 结果以及新的成像表型的快速开发和验证。开发的方法 在目前的周期中，已经证明在人类研究中是稳健的和高精度的。 以及在使用啮齿动物和非人灵长类动物的翻译模型中。在本周期内，BIRC已 通过支持3，431次图像采集（DXA、CT、MRI），为OAIC的巨大成功做出了巨大贡献 和PET）的10个外部资助的研究，8个试点研究和3个研究发展项目。 生物成像资源核心的具体目标是：1）确定年龄和 骨骼肌和脂肪组织库中的疾病相关变化与生物学、遗传学、共病， 心理社会和行为因素，以及其他与身体功能相关的结果; 2）测量影响 对脂肪和骨骼的干预（饮食/营养，运动，药物和组合） 肌肉组织库; 3）使用体内生物成像，以实现关键发现在 人类和动物模型（包括非人类灵长类动物），以支持机制研究; 4）开发 并验证允许骨骼肌的改进表征的新的非侵入性成像度量， 老年人的脂肪组织和血管功能与一系列标准化的身体检查相结合。 功能和实验室/分子评估。 BIRC领导团队是经验丰富和成功的调查人员，他们在战略上 互补的技能组合和合作科学和行政成就的良好记录。在 在首年，BIRC将支持7个外部资助项目，2个试点项目和1个发展项目 项目BIRC还将向刚果民盟支持的教师提供培训和指导， 成像技术，并推动他们作为独立的转化研究科学家的发展。