CLONIDINE-INDUCED SPRINAL ACETYLCHOLINE RESEARCH

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该方案是疼痛中心赠款的一部分，重点关注疼痛本身，特别是慢性神经性疼痛，如何改变对传统和非传统止痛药的反应。神经纤维将疼痛信息传递到大脑的方式被认为在手术后和慢性疼痛中发生了变化。出于这个原因，与手术后或慢性疼痛的人相比，一些药物在缓解突然疼痛的健康人身上的疼痛方面效果更好。目前可用的止痛药可能不能缓解所有类型的疼痛，或者只能在产生副作用和潜在并发症的剂量下缓解疼痛。该方案的目的是通过观察服用可乐定前后健康人的脑脊液以及患有慢性神经病理性神经疼痛的人的脊髓液，来了解鞘内可乐定增加效力和疗效的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol is part of a Pain Center Grant that focuses on how pain itself, especially chronic neuropathic pain, alters the response to traditional and non-traditional analgesics. The way that nerve fibers carry the information of pain to the brain is thought to change after surgery and in chronic pain. For this reason, some medicines work better to relieve pain in healthy people who have a sudden painful injury compared to those after surgery or those with chronic pain. Currently available pain medications may not relieve all types of pain or may relieve pain only at doses that produce side effects and potential complications. The aim of this protocol is to understand the mechanisms by which intrathecal clonidine increases in potency and efficacy by looking at the cerebrospinal fluid of healthy individuals before and after clonidine administration as well as looking at the spinal fluid of people that have chronic neuropathic nerve pain.