CAROTID ATHEROSCLEROSIS (MRI) PROGRESSION STUDY (CAMPS)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究将检验这一假设，即在两年内，使用磁共振成像(MRI)测量的颈动脉壁和斑块体积在冠心病(CAD)患者中比非CAD对照组增加得更快。参与者将从以前参加过我们的非侵入性成像研究的患者中招募。这些患者被选为平均包括男性和女性患者，这些患者都有已知的冠心病和冠状动脉造影术定义的无疾病对照。我们建议从以前的研究中招募200名参与者。根据要求，我们将从维克森林健康科学中心的心导管检查登记处招募更多的患者。在基线时，参与者将被同意并就病史和当前药物进行访谈，抽血，测量生命体征，接受心电检查，并测量踝臂血压比。参与者接下来将接受颈动脉的核磁共振扫描。有(n=15)和没有(n=15)糖尿病和颈动脉斑块的参与者的子组也将被要求进行Gd增强MRI(含造影剂的MRI)。100名参与者还将仅在基线时接受颈动脉B型超声检查。参与者将在两年后返回，程序将重复。参与者将在基线和后续扫描之间每6个月联系一次，并在此后3年内确定心血管事件。可能怀孕的女性受试者将不被允许参加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will test the hypothesis that carotid artery wall and plaque volume measured using magnetic resonance imaging (MRI) increases more rapidly in patients with coronary artery disease (CAD) than CAD-free controls over 2 years. Participants will be recruited from patients who previously participated in our non-invasive imaging studies. These patients were chosen to equally include male and female patients with known CAD and disease-free controls as defined at coronary angiography. We propose to recruit 200 participants from the previous studies. As required, we will recruit additional patients from the Wake Forest Health Sciences cardiac catheterization registry. At baseline, participants will be consented and interviewed about medical history and current medications, have blood drawn, vital signs measured, receive an ECG, and have ankle-brachial blood pressure ratio measured. Participants will next undergo an MRI scan of the carotid arteries. A subset of participants with (n=15) and without (n=15) diabetes and carotid plaques will be asked to have a gadolinium-enhanced MRI (MRI with contrast agent) as well. One hundred participants will also receive carotid artery B-mode ultrasound at baseline only. Participants will return in 2 years, and the procedures will be repeated. Participants will be contacted every 6 months between baseline and follow-up scans and for 3 years thereafter to ascertain cardiovascular events. Female subjects who might be pregnant will not be allowed to participate.