CAROTID ATHEROSCLEROSIS (MRI) PROGRESSION STUDY (CAMPS)

颈动脉粥样硬化 (MRI) 进展研究（CAMPS）

• 批准号: 7607691
• 负责人: JOHN R CROUSE
• 金额: $ 0.31万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607691
• 关键词: Ankle; Blood; Blood Pressure; Cardiac Catheterization Procedures; Cardiovascular system; Carotid Arteries; Carotid Artery Plaques; Computer Retrieval of Information on Scientific Projects Database; Consent; Contrast Media; Coronary Angiography; Coronary Arteriosclerosis; Diabetes Mellitus; Disease; Electrocardiogram; Event; Female; Funding; Gadolinium; Grant; Health Sciences; Image; Institution; Interview; Invasive; Magnetic Resonance Imaging; Measures; Medical History; Participant; Patient currently pregnant; Patients; Pharmaceutical Preparations; Procedures; Recruitment Activity; Registries; Research; Research Personnel; Resources; Scanning; Source; Testing; Ultrasonography; United States National Institutes of Health; follow-up; forest; male

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will test the hypothesis that carotid artery wall and plaque volume measured using magnetic resonance imaging (MRI) increases more rapidly in patients with coronary artery disease (CAD) than CAD-free controls over 2 years. Participants will be recruited from patients who previously participated in our non-invasive imaging studies. These patients were chosen to equally include male and female patients with known CAD and disease-free controls as defined at coronary angiography. We propose to recruit 200 participants from the previous studies. As required, we will recruit additional patients from the Wake Forest Health Sciences cardiac catheterization registry. At baseline, participants will be consented and interviewed about medical history and current medications, have blood drawn, vital signs measured, receive an ECG, and have ankle-brachial blood pressure ratio measured. Participants will next undergo an MRI scan of the carotid arteries. A subset of participants with (n=15) and without (n=15) diabetes and carotid plaques will be asked to have a gadolinium-enhanced MRI (MRI with contrast agent) as well. One hundred participants will also receive carotid artery B-mode ultrasound at baseline only. Participants will return in 2 years, and the procedures will be repeated. Participants will be contacted every 6 months between baseline and follow-up scans and for 3 years thereafter to ascertain cardiovascular events. Female subjects who might be pregnant will not be allowed to participate.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究将验证以下假设：在 2 年内，使用磁共振成像 (MRI) 测量的颈动脉壁和斑块体积在患有冠状动脉疾病 (CAD) 的患者中比无 CAD 对照的患者增加得更快。参与者将从之前参加过我们的非侵入性成像研究的患者中招募。这些患者被选择为平等地包括患有已知 CAD 的男性和女性患者以及冠状动脉造影定义的无疾病对照患者。我们建议从之前的研究中招募 200 名参与者。根据需要，我们将从维克森林健康科学心导管登记处招募更多患者。 在基线时，参与者将获得同意并接受有关病史和当前药物治疗的采访，抽血，测量生命体征，接受心电图，并测量踝臂血压比。接下来，参与者将接受颈动脉核磁共振扫描。患有 (n=15) 和不患有 (n=15) 糖尿病和颈动脉斑块的参与者子集也将被要求进行钆增强 MRI（使用造影剂的 MRI）。一百名参与者还将仅在基线时接受颈动脉 B 型超声检查。参与者将在两年后返回，并重复该程序。在基线扫描和后续扫描之间每 6 个月以及此后 3 年将与参与者联系，以确定心血管事件。 可能怀孕的女性受试者将不被允许参加。