HYDROXYPROLIINE AND URINARY OXALATE EXCRETION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。当食用胶原蛋白和明胶时，它们在体内部分分解，产生小的有机酸。这些酸包括甘氨酸、乙醛酸、乙醇酸和草酸。草酸盐是肾结石的主要成分，其合成是一个病理问题。在一些患有遗传性疾病的个体中，羟脯氨酸的代谢可能受损，并且可能形成过量的草酸盐。在本项目中，将在正常个体中测量明胶代谢为这些有机酸。个体将食用含有明胶或蛋蛋白作为饮食的一部分的已知组成的饮食。将在血液和尿液样本中测量有机酸的形成。这项研究将揭示胶原或明胶的分解是否与正常人的草酸盐形成有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. When collagen and gelatin are eaten, they are broken down in the body in part to yield small organic acids. These acids include glycine, glyoxylate, glycolate, and oxalate. Oxalate is a major component of kidney stones and its synthesis is of pathologic concern. In some individuals with genetic diseases, the metabolism of hydroxyproline may be impaired, and excessive amounts of oxalate may be formed. In this project, the metabolism of gelatin to these organic acids will be measured in normal individuals. Individuals will consume diets of known composition that contain either gelatin or egg protein as part of the diet. The formation of organic acids will be measured in blood and urine samples. This study should reveal whether collagen or gelatin breakdown is associated with oxalate formation in normal individuals.