HYDROXYPROLIINE AND URINARY OXALATE EXCRETION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. When collagen and gelatin are eaten, they are broken down in the body in part to yield small organic acids. These acids include glycine, glyoxylate, glycolate, and oxalate. Oxalate is a major component of kidney stones and its synthesis is of pathologic concern. In some individuals with genetic diseases, the metabolism of hydroxyproline may be impaired, and excessive amounts of oxalate may be formed. In this project, the metabolism of gelatin to these organic acids will be measured in normal individuals. Individuals will consume diets of known composition that contain either gelatin or egg protein as part of the diet. The formation of organic acids will be measured in blood and urine samples. This study should reveal whether collagen or gelatin breakdown is associated with oxalate formation in normal individuals.