ORAL IMMUNE DYSFUNCTION AND ORAL INFECTIOUS DISEASE IN HIV INFECTION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这是一项研究，旨在确定艾滋病病毒是否会影响口腔中的免疫系统，以及这如何在口腔感染(口腔鹅口疮、疣、溃疡、口干、牙周炎)中造成易感性。这项研究旨在通过研究有口腔感染和无口腔感染的HIV阳性和HIV阴性者的免疫系统，更好地了解艾滋病毒感染者容易发生口腔感染的原因。这项研究将调查女性对艾滋病毒感染者常见的几种口腔感染的口腔免疫和血液免疫以及阴道免疫，这些感染包括口腔酵母菌感染、口腔溃疡、口腔疣、毛发白斑、溃疡性牙周炎和口腔炎。血细胞或阴道冲洗液(仅限女性)中的免疫反应与口腔洗涤液或口腔活检中的免疫反应相比，将在患有和不患有口腔感染的HIV阳性和HIV阴性患者之间进行比较。这将有助于显示目前的免疫类型，以及艾滋病毒感染者的口腔免疫状态是否存在缺陷，从而容易受到口腔感染。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a research study to identify whether the AIDS virus affects the immune system in the mouth, and how this creates susceptibility in infections in the mouth (oral thrush, warts, ulcers, dry mouth, periodontitis). This research study aims to better understand why HIV-infected individuals are prone to oral infections through studying the immune system of HIV-positive and HIV-negative people, with and without oral infections. The study will investigate the oral and blood immunity, as well as vaginal immunity in women, to several oral infections common in HIV-positive persons, including oral yeast infections, oral ulcers, oral warts, hairy leukoplakia, ulcerative periodontitis, and stomatitis. Immune responses, or lack thereof, in the blood cells or vaginal wash (women only) compared to that in oral washes or oral biopsies will be compared between HIV-positve and HIV-negative individuals with and without oral infections. This will help show the type of immunity present and whether individuals with HIV infection are deficient in their oral immune status such that they are prone to oral infections.