GENERAL CLINICAL RESEARCH CENTER

超出空间 但前提是。 此申请是为位于以下位置的多类别综合临床研究中心进行竞争性续签 在辛辛那提儿童医院。该中心提供住院、门诊和分散床位设施 在儿童医院和一个支持生化分析的核心实验室内，身体成分 儿童医院的测量和行为研究。建议在退伍军人中心发射一颗卫星 管理医疗中心将帮助支持对不适合于健康状况不稳定的成年人的研究 在GCRC儿童医院学习。主要研究领域包括： 1.心血管疾病：研究正在确定胆固醇吸收的不同在 胆固醇代谢，高血压和慢性肾脏疾病等疾病状态的影响 儿童心脏和血管功能及解剖学。 2.行为干预：研究正在探索行为干预在提高营养方面的效果 囊性纤维化、镰状细胞病、克罗恩病和其他疾病的摄入量和评估早期 创伤性脑损伤对后期神经认知发育的影响。 3.癌症：正在进行新的研究，评估Rapammune和类似化合物对 结节性硬化症和淋巴管肌瘤病合并血管脂肪瘤的治疗 除了手术外，没有其他有效的治疗方法可用。 4.肥胖：研究正在确定早年身体成分的变化对肥胖发展的作用 后来的肥胖，研究了青春期身体成分的种族差异，以及 肥胖对睡眠障碍和碳水化合物代谢的影响。 5.基因转移：已经在GCRC启动了基因转移试验，以评估插入 野生型基因进入范可尼贫血患者的干细胞是否安全，最终是否会 在纠正潜在的骨髓缺陷方面是有效的。 6.糖尿病：2型糖尿病和肥胖对心脏和血管结构的影响 正在对青少年的功能进行评估。促胰岛素Gl激素-胰升糖素样肽-1的作用 (GLP-1)在正常和2型糖尿病患者的胃排空和胰岛素分泌中的作用正在检测中，其 在2型糖尿病中的作用。 7.胆汁酸代谢的先天性错误：有长期研究和发现多发性胆汁酸的记录 胆汁酸合成途径中的酶缺陷，儿童医院的研究人员继续 提高对这些缺陷影响胆汁淤积和脂溶的婴幼儿的认识 维生素缺乏。

EXCEED THE SPACE PROVIDED. This application is for a competitive renewal of a multi-categorical General Clinical Research Center located at the Children's Hospital of Cincinnati. The Center provides inpatient, outpatient and scatter bed facilities within the Children's Hospital and a Core Laboratory supporting biochemical assays, body composition measurements, and behavioral studies at the Children's Hospital. A proposed satellite at the Veterans Administration Medical Center will help support studies in medically unstable adults who are not suitable to be studied at the Children's Hospital GCRC. Major areas of research include: 1. Cardiovascular disease: Studies are defining the potential role of differences in cholesterol absorption on cholesterol metabolism, the effects of disease states such as hypertension and chronic renal disease in children on cardiac and vascular function and anatomy. 2. Behavioral Interventions: Studies are exploring the effect of behavioral intervention in enhancing nutrient intake in cystic fibrosis, sickle cell disease, Crohn's Disease and others and assessing the impact of early traumatic brain injury on later neurocognitive development. 3. Cancer: Novel investigations are ongoing evaluating the effect of rapammune and similar compounds for the treatment of angiolipomata associated with tuberous sclerosis and lymphangioleiomyomatosis (LAMS) for whom no effective therapy other than surgery is available. 4. Obesity: Studies are defining the roles of changes in body composition in early life on the development of later obesity, examining racial disparities in body composition which occur during adolescence, and the impact of obesity on sleep disturbances and carbohydrate metabolism. 5. Gene Transfer: Gene transfer trials have been initiated at the GCRC to evaluate whether insertion of a wild type gene into the stem cells of patients with Fanconi Anemia will be safe and ultimately whether it will be efficacious in correcting their underlying bone marrow defects. 6. Diabetes Mellitus: The impact of Type 2 diabetes and obesity on cardiac and vascular structure and function in adolescents is being evaluated. The role of the insulinotropic Gl hormone glucagon-like peptide 1 (GLP-1) in gastric emptying and insulin secretion in normal and Type 2 diabetics is being examined and its role in type 2 diabetes. 7. Inborn errors of bile acid metabolism: With a long track record of research and discovery of multiple enzymatic defects in the bile acid synthetic pathways, investigators at Children's Hospital continue to enhance understanding of these defects affecting infants and children with cholestasis and fat soluble vitamin deficiencies.