Pediatric Center--Gene Expression /Developmental Science

描述（由申请人提供）：本申请用于继续 为我们的儿童健康研究职业发展奖 (CHRCDA) 提供资金，该奖 建立了一个独特的卓越中心，以增强基础和 儿科临床研究培训，重点关注分子和细胞 生物学和临床科学。 该中心增强了学术生涯 培养初级儿科教师，提供指导和核心 旨在根据需要加强儿科医生培训的设施 学术生涯。 该中心已纳入既定计划 研究培训：Procter Scholar 计划和 NIH 的广泛资助 研究计划。 该计划识别并招募有前途的初级人才 完成 2-3 年研究增强计划的儿科教师 CHRCDA 项目由资深科学家导师组成，他们共享一个 分子细胞生物学、分子医学或临床的中心焦点 科学。 职业发展包括：1）中心的个人指导 工作人员调查员； 2) 分子遗传学方面的正式和非正式培训 发育生物学、临床研究和流行病学以及 NIH 资助的 临床研究中心（CRC）、流行病学和统计学； 3）核心 将优先考虑分子生物学培训的研究要素， 免疫学、蛋白质纯化和转基因模型； 4）核心研究 支持流行病学和临床研究技能。 现在的 应用程序汇集了在以下方面具有卓越成就的研究人员 儿童医院和大学的发展科学 辛辛那提医学院。 为了实现我们的培训目标，由四部分组成 建议中心： 1) 中心工作人员具有共同兴趣和 分子和细胞生物学和信息学应用方面的专业知识 哺乳动物发育研究、分子医学和 临床研究是儿科医生学者的主要导师； 2） 行政核心确定新兵并监督整体培训 儿科医生学者。 核心为国家提供支持 地方和国家层面的招聘工作并优先考虑少数族裔 招聘； 3）研究核心促进分子和技术的应用 细胞生物学和临床研究/流行病学和统计学 儿科医生学者的研究计划。 研究核心要素包括 分子生物学核心、信息学支持、临床研究设计 支持和转基因小鼠核心。 其他可用的核心包括杂交瘤、 蛋白质分析、分子形态学、基因阵列信息学和研究 设计，将提供培训和技术援助。 4） 研究支持拨款提供儿科医生学者研究资金和 指导期最长为三年。 这个联合计划的 当代分子的个人指导和高级培训， 细胞、发育生物学和临床科学增强了培训 以及我们儿科医生学者的研究生产力，因为他们的起点很高 儿科科学领域富有成效的学术生涯。

DESCRIPTION (provided by applicant): This application is for continued funding for our Child Health Research Career Development Award (CHRCDA), which has established a unique center of excellence for the enhancement of basic and clinical research training in pediatrics with foci on molecular and cellular biology and clinical sciences. The center enhances the academic career development of junior pediatric faculty, providing mentorship and Core facilities designed to enhance the training of pediatricians as required for an academic career. The Center is integrated into established programs for research training: the Procter Scholar program and extensive NIH funded research programs. The program identifies and recruits promising junior pediatric faculty who complete a 2-3 year program for research enhancement within a CHRCDA program comprised of senior scientist mentors who share a central focus in molecular-cellular biology, molecular medicine or clinical sciences. Career development includes: 1) individual mentorship by Center staff investigators; 2) formal and informal training in molecular genetics and developmental biology, clinical research and epidemiology and an NIH-funded Clinical Research Center (CRC), and epidemiology and statistics; 3) Core research elements which will prioritize training in molecular biology, immunology, protein purification and transgenic models; and 4) Core research support for epidemiology and clinical research skills. The present application has drawn together established investigators with excellence in developmental science at the Children's Hospital and the University of Cincinnati College of Medicine. To meet our training goals, a four-part center is proposed: 1) Center Staff Investigators who share interest and expertise in the application of molecular and cellular biology and informatics technology in the study of mammalian development, molecular medicine, and clinical research serve as primary mentors for the Pediatrician-Scholars; 2) The Administrative Core identifies recruits, and monitors the overall training of the Pediatrician-Scholars. The Core provides support for national recruitment efforts at local and national levels and prioritizes minority recruitment; 3) Research Cores facilitate the application of molecular and cellular biology and clinical research/epidemiology and statistics to the research programs of Pediatrician-Scholars. Research Core elements include Molecular Biology Cores, informatics support, clinical research study design support and Transgenic Mouse Cores. Other Cores available include Hybridoma, Protein Analysis, Molecular Morphology, Gene Array Informatics, and Study Design, which will provide both training and technical assistance. 4) Research support grants provide the Pediatrician-Scholar research funds and mentorship for a period of up to three years. This combined program of individual mentorship and advanced training in contemporary molecular, cellular, developmental biology and clinical sciences enhances the training and research productivity of our Pediatrician-Scholars as they begin highly productive academic careers in pediatric science.