Pediatric Center--Gene Expression /Developmental Science

儿科中心--基因表达/发育科学

• 批准号: 7002642
• 负责人: THOMAS F BOAT
• 金额: $ 38.85万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-20 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7002642
• 关键词: biomedical facility; clinical research; epidemiology; gene expression; genome; genotype; growth /development; health science profession; health science research support; human subject; informatics; molecular biology; monoclonal antibody; nucleic acid sequence; pediatrics; protein purification; role model; statistics /biometry; training

DESCRIPTION (provided by applicant): This application is for continued funding for our Child Health Research Career Development Award (CHRCDA), which has established a unique center of excellence for the enhancement of basic and clinical research training in pediatrics with foci on molecular and cellular biology and clinical sciences. The center enhances the academic career development of junior pediatric faculty, providing mentorship and Core facilities designed to enhance the training of pediatricians as required for an academic career. The Center is integrated into established programs for research training: the Procter Scholar program and extensive NIH funded research programs. The program identifies and recruits promising junior pediatric faculty who complete a 2-3 year program for research enhancement within a CHRCDA program comprised of senior scientist mentors who share a central focus in molecular-cellular biology, molecular medicine or clinical sciences. Career development includes: 1) individual mentorship by Center staff investigators; 2) formal and informal training in molecular genetics and developmental biology, clinical research and epidemiology and an NIH-funded Clinical Research Center (CRC), and epidemiology and statistics; 3) Core research elements which will prioritize training in molecular biology, immunology, protein purification and transgenic models; and 4) Core research support for epidemiology and clinical research skills. The present application has drawn together established investigators with excellence in developmental science at the Children's Hospital and the University of Cincinnati College of Medicine. To meet our training goals, a four-part center is proposed: 1) Center Staff Investigators who share interest and expertise in the application of molecular and cellular biology and informatics technology in the study of mammalian development, molecular medicine, and clinical research serve as primary mentors for the Pediatrician-Scholars; 2) The Administrative Core identifies recruits, and monitors the overall training of the Pediatrician-Scholars. The Core provides support for national recruitment efforts at local and national levels and prioritizes minority recruitment; 3) Research Cores facilitate the application of molecular and cellular biology and clinical research/epidemiology and statistics to the research programs of Pediatrician-Scholars. Research Core elements include Molecular Biology Cores, informatics support, clinical research study design support and Transgenic Mouse Cores. Other Cores available include Hybridoma, Protein Analysis, Molecular Morphology, Gene Array Informatics, and Study Design, which will provide both training and technical assistance. 4) Research support grants provide the Pediatrician-Scholar research funds and mentorship for a period of up to three years. This combined program of individual mentorship and advanced training in contemporary molecular, cellular, developmental biology and clinical sciences enhances the training and research productivity of our Pediatrician-Scholars as they begin highly productive academic careers in pediatric science.

说明（由申请人提供）：本申请为续 为我们的儿童健康研究职业发展奖（CHRCDA）提供资金， 建立了一个独特的卓越中心，以提高基础和 以分子和细胞为重点的儿科临床研究培训 生物学和临床科学。 该中心提高了学术生涯 发展初级儿科教师，提供指导和核心 旨在加强儿科医生培训的设施， 学术生涯 该中心被纳入既定方案， 研究培训：Procter Scholar计划和广泛的NIH资助 研究项目。 该计划确定并招募有前途的年轻人 完成2-3年研究增强计划的儿科教师 在一个由资深科学家导师组成的CHRCDA计划中， 分子细胞生物学、分子医学或临床 以理工科为重 职业发展包括：1）中心的个人指导 工作人员调查员; 2）分子遗传学方面的正式和非正式培训， 发育生物学、临床研究和流行病学以及NIH资助的 临床研究中心（CRC），流行病学和统计学; 3）核心 优先考虑分子生物学培训的研究要素， 免疫学、蛋白质纯化和转基因模型; 4）核心研究 支持流行病学和临床研究技能。 本 应用程序已经吸引了优秀的既定调查人员， 发展科学在儿童医院和大学 辛辛那提医学院。 为了实现我们的培训目标， 拟定的研究中心：1）共同利益的研究中心工作人员， 分子和细胞生物学及信息学应用方面的专业知识 研究哺乳动物发育的技术，分子医学， 临床研究作为儿科医生学者的主要导师; 2） 行政核心确定新成员，并监督总体培训 儿科医生学者 核心为国家提供支持 在地方和国家两级开展征聘工作， 3）研究核心促进了分子和 细胞生物学和临床研究/流行病学和统计学 儿科学者的研究计划。 研究核心要素包括 分子生物学核心，信息学支持，临床研究设计 支持和转基因小鼠核心。 其他可用的内核包括Hybrid， 蛋白质分析、分子形态学、基因阵列信息学和研究 设计，将提供培训和技术援助。 四、 研究支持赠款提供儿科学者研究基金， 指导期最长为三年。 这一联合方案 个人指导和现代分子， 细胞、发育生物学和临床科学增强了培训 和我们的儿科医生学者的研究生产力，因为他们开始高度 在儿科科学领域的学术成就

项目成果

Interleukin-15 inhibits sodium nitroprusside-induced apoptosis of synovial fibroblasts and vascular endothelial cells.

Interleukin-15 抑制硝普钠诱导的滑膜成纤维细胞和血管内皮细胞凋亡。

• DOI: 10.1002/art.10610
• 发表时间: 2002
• 期刊: Arthritis and rheumatism.
• 作者: Yang,Lin;Thornton,Sherry;Grom,AlexeiA
• 通讯作者: Grom,AlexeiA

Etanercept in the treatment of macrophage activation syndrome.

• 发表时间: 2001-09
• 期刊: The Journal of rheumatology
• 作者: S. Prahalad;K. Bove;D. Dickens;D. Lovell;A. Grom

Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.

• DOI: 10.1161/circulationaha.108.798983
• 发表时间: 2009-03-10
• 期刊: Circulation
• 影响因子: 37.8
• 作者: Sadayappan S;Gulick J;Klevitsky R;Lorenz JN;Sargent M;Molkentin JD;Robbins J
• 通讯作者: Robbins J