Pediatric Center--Gene Expression /Developmental Science

描述(申请人提供)：本申请为续展申请 为我们的儿童健康研究职业发展奖(CHRCDA)提供资金， 建立了一个独特的卓越中心，以增强基础和 以分子和细胞为重点的儿科临床科研培训 生物学和临床科学。该中心促进了学术事业的发展 发展初级儿科教师，提供导师和核心 旨在加强儿科医生培训的设施，以满足 学术生涯。该中心被整合到既定的计划中， 研究培训：普罗科特学者计划和广泛的NIH资助 研究项目。该计划确定并招募有前途的初级人才。 完成2-3年研究强化计划的儿科教员 在CHRCDA计划中，由资深科学家导师组成，他们共享 分子细胞生物学、分子医学或临床研究的中心焦点 科学。职业发展包括：1)中心的个人指导 工作人员调查人员；2)分子遗传学和 发育生物学、临床研究和流行病学与美国国立卫生研究院资助的 临床研究中心(CRC)、流行病学和统计学；3)核心 将分子生物学培训放在首位的研究要素 免疫学、蛋白质纯化和转基因模型；4)核心研究 支持流行病学和临床研究技能。现在 应用程序将资深调查人员聚集在一起，他们在 儿童医院和加州大学的发展科学 辛辛那提医学院。为了达到我们的培训目标，我们分四个部分 中心建议：1)中心工作人员共同感兴趣和 分子和细胞生物学及信息学应用方面的专门知识 哺乳动物发育研究中的技术、分子医学和 临床研究是儿科医生-学者的主要导师；2) 行政核心确定招募人员，并监督整个培训 儿科医生-学者。核心为国家提供支持 地方和国家一级的招聘工作，优先考虑少数群体 招募；3)研究核心促进分子和 细胞生物学和临床研究/流行病学和统计 儿科医生-学者的研究计划。研究的核心要素包括 分子生物学核心、信息学支持、临床研究研究设计 支持和转基因小鼠核心。其他可用的核心包括杂交瘤， 蛋白质分析、分子形态、基因阵列信息学及其研究 设计，将提供培训和技术援助。4) 研究支助补助金提供儿科医生-学者研究基金和 为期最长三年的导师制。这一综合计划 当代分子方面的个人指导和高级培训， 细胞、发育生物学和临床科学加强了培训 我们的儿科医生和学者的研究效率很高 在儿科科学领域从事富有成效的学术事业。

DESCRIPTION (provided by applicant): This application is for continued funding for our Child Health Research Career Development Award (CHRCDA), which has established a unique center of excellence for the enhancement of basic and clinical research training in pediatrics with foci on molecular and cellular biology and clinical sciences. The center enhances the academic career development of junior pediatric faculty, providing mentorship and Core facilities designed to enhance the training of pediatricians as required for an academic career. The Center is integrated into established programs for research training: the Procter Scholar program and extensive NIH funded research programs. The program identifies and recruits promising junior pediatric faculty who complete a 2-3 year program for research enhancement within a CHRCDA program comprised of senior scientist mentors who share a central focus in molecular-cellular biology, molecular medicine or clinical sciences. Career development includes: 1) individual mentorship by Center staff investigators; 2) formal and informal training in molecular genetics and developmental biology, clinical research and epidemiology and an NIH-funded Clinical Research Center (CRC), and epidemiology and statistics; 3) Core research elements which will prioritize training in molecular biology, immunology, protein purification and transgenic models; and 4) Core research support for epidemiology and clinical research skills. The present application has drawn together established investigators with excellence in developmental science at the Children's Hospital and the University of Cincinnati College of Medicine. To meet our training goals, a four-part center is proposed: 1) Center Staff Investigators who share interest and expertise in the application of molecular and cellular biology and informatics technology in the study of mammalian development, molecular medicine, and clinical research serve as primary mentors for the Pediatrician-Scholars; 2) The Administrative Core identifies recruits, and monitors the overall training of the Pediatrician-Scholars. The Core provides support for national recruitment efforts at local and national levels and prioritizes minority recruitment; 3) Research Cores facilitate the application of molecular and cellular biology and clinical research/epidemiology and statistics to the research programs of Pediatrician-Scholars. Research Core elements include Molecular Biology Cores, informatics support, clinical research study design support and Transgenic Mouse Cores. Other Cores available include Hybridoma, Protein Analysis, Molecular Morphology, Gene Array Informatics, and Study Design, which will provide both training and technical assistance. 4) Research support grants provide the Pediatrician-Scholar research funds and mentorship for a period of up to three years. This combined program of individual mentorship and advanced training in contemporary molecular, cellular, developmental biology and clinical sciences enhances the training and research productivity of our Pediatrician-Scholars as they begin highly productive academic careers in pediatric science.