PAROXETINE & SILDENAFIL ON PHARMACOKINETICS OF METOPROLOL, CARVEDILOL, & ATENOLO

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。有许多药物相互作用被认为发生，但没有很好地描述。这包括一种叫做-受体阻滞剂的药物（在这项研究中，这些药物包括美托洛尔、美托洛尔缓释、卡维地洛和阿替洛尔）和另外两种药物之间的药物相互作用，一种是抗抑郁药帕罗西汀（帕罗西汀），一种是治疗性功能障碍的药物西地那非（伟哥）。在这项研究中，将招募正常的志愿者。受试者将被随机分配到研究小组。主要结果将是不同的-受体阻滞剂在与相互作用的药物（帕罗西汀和伟哥）一起服用时如何从体内消除，以及相互作用的药物如何影响-受体阻滞剂对心率和血压的影响。这项研究的结果将有助于更好地了解如何将这些药物一起使用，以更安全地治疗患者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are many drug interactions that are thought to occur but are not well described. This includes drug interactions between a class of drugs called beta-blockers (for this study these drugs will include metoprolol, metoprolol extended release, carvedilol, and atenolol) and two other drugs, an antidepressant called paroxetine (Paxil) and a drug for sexual dysfunction called sildenafil (Viagra). For this study, normal volunteers will be recruited. Subjects will be randomly assigned to study groups. The primary outcomes will be changes in how the different beta-blockers are eliminated from the body when administered with the interacting drugs (Paxil and Viagra) and how the interacting drugs may affect beta blocker effects on heart rate and blood pressure The results of this study will lead to a better understanding on how to use these drugs together to treat patients more safely.