PAROXETINE & SILDENAFIL ON PHARMACOKINETICS OF METOPROLOL, CARVEDILOL, & ATENOLO

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。有许多药物相互作用被认为发生了，但没有得到很好的描述。这包括一类名为β-受体阻滞剂的药物(在本研究中，这些药物将包括美托洛尔、美托洛尔缓释剂、卡维地洛和阿替洛尔)与另外两种药物之间的药物相互作用，这两种药物分别是抗抑郁药帕罗西汀(帕罗西汀)和治疗性功能障碍的药物西地那非(伟哥)。在这项研究中，将招募正常志愿者。受试者将被随机分配到研究组。主要结果将是不同的β-受体阻滞剂与相互作用的药物(帕罗西汀和伟哥)一起服用时如何从体内消除的变化，以及相互作用的药物可能如何影响β-受体阻滞剂对心率和血压的效果。这项研究的结果将使人们更好地理解如何联合使用这些药物来更安全地治疗患者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are many drug interactions that are thought to occur but are not well described. This includes drug interactions between a class of drugs called beta-blockers (for this study these drugs will include metoprolol, metoprolol extended release, carvedilol, and atenolol) and two other drugs, an antidepressant called paroxetine (Paxil) and a drug for sexual dysfunction called sildenafil (Viagra). For this study, normal volunteers will be recruited. Subjects will be randomly assigned to study groups. The primary outcomes will be changes in how the different beta-blockers are eliminated from the body when administered with the interacting drugs (Paxil and Viagra) and how the interacting drugs may affect beta blocker effects on heart rate and blood pressure The results of this study will lead to a better understanding on how to use these drugs together to treat patients more safely.