ACTIVITY PACING AND SYMPTOMS IN OLDER ADULTS WITH OSTEOARTHRITIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。骨关节炎是老年人致残的主要原因。下肢骨关节炎（LE-OA）与影响活动表现的疼痛和疲劳症状相关。对于患有LE-OA的老年人在日常生活中是如何经历这些症状的，以及他们为应对这些症状而做出的适应，人们知之甚少，尽管这些适应被认为会影响残疾。该项目将研究适应与疼痛和疲劳症状之间的关系，重点关注一个关键的适应、活动节奏（例如，使用平衡活动与休息的策略）和使用实时测量方法（例如，活动评分设备）。将从密歇根大学老年医学中心的研究参与者计划中招募60名年龄在55-80岁之间的女性：40名患有痛觉限制的LE-OA， 20名健康对照。所有前来筛选的感兴趣的受访者都将被告知这项研究并被要求签署同意书。膝关节或髋关节骨关节炎将首先通过x线片确认。然后根据美国风湿病学会的临床标准确定疼痛限制型髋关节或膝关节骨关节炎。参与者将回答有关人口统计和身体功能的基本问题，并参与步态，力量和平衡的身体性能评估。然后，参与者将接受佩戴运动计分设备的指导。该设备将佩戴在手腕上五天，参与者将在一天中的五个时间点收到提示。在每个时间点，参与者将把他们使用活动的频率、节奏、疼痛和疲劳程度输入到设备中。所有收集到的数据将被编入计算机数据库，参与者将只通过身份证号码识别身份。签署的知情同意书和身份证号码与参与者姓名相匹配的总名单将保存在首席研究员办公室的一个上锁的抽屉里。该项目的具体目的是：1)在5天的时间内检查与LE-OA相关症状的经历，将患有下肢OA （LE-OA）的老年妇女的疼痛和疲劳水平的每日变化（例如，每日变化）与健康对照妇女进行比较；2)在5天的测试期间，检查患有LE-OA的老年妇女与对照组的活动起搏、疼痛和疲劳之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoarthritis is a leading cause of disability among older adults. Lower extremity osteoarthritis (LE-OA) is associated with symptoms of pain and fatigue that affect activity performance. Little is known about how older adults with LE-OA experience these symptoms in everyday life or the adaptations they make in response even though these adaptations are thought to influence disability. This project will investigate the relationship between adaptation and pain and fatigue symptoms by focusing on one key adaptation, activity pacing (e.g. use of strategies that balance activities with rest) and by using a real-time measurement method (e.g. acti-score devices). Sixty females aged 55-80 will be recruited from the Research Participant Program of the University of Michigan s Geriatric Center: 40 with pain-limiting LE-OA and 20 healthy controls. All interested respondents who come for screening will be informed about the study and asked to sign the consent form. Knee or hip osteoarthritis will be determined first through radiographic confirmation. Pain-limiting hip or knee osteoarthritis will then be determined by using the American College of Rheumatology s clinical criteria. Participants will answer basic questions regarding demographics and physical function and will participate in physical performance assessments of gait, strength, and balance. Then participants will receive instruction on wearing the acti-score devices. Devices will be worn on the wrist for five days and participants will be prompted at five time-points throughout the day. At each time-point, participants will input their frequency of using activity pacing and pain and fatigue levels into the device. All data collected will be compiled into computer databases in which participants will only be identified from an ID number. Signed informed consent forms and a master list that matches ID numbers with participant names will be kept in a locked drawer in the principal investigator s office. The specific aims of this project are 1) To examine the experience of LE-OA-related symptoms over a five-day period, the diurnal (e.g., daily) variations of pain and fatigue levels of older women with lower extremity OA (LE-OA) will be compared to healthy women controls and 2) To examine the relationship between activity pacing, pain, and fatigue among older women with LE-OA and the control group over a five day testing period.