MICROPARTICLES AND SELECTINS IN INFLAMMATORY BOWEL DISEASES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。微粒是炎症期间从白细胞、血小板和排列血管的细胞(内皮细胞)中释放出来的小块细胞。已经发现，患有多发性硬化症、心脏病发作、血液中的细菌感染以及其他几种炎症起重要作用的疾病的患者体内微粒含量会增加。微粒似乎有助于白血球和血小板附着在炎症区域的血管壁上。这可能会导致炎症和血液凝结的增加。选择素是一种黏附分子，可以帮助微粒和血细胞附着在血管壁上。在一些炎症性疾病中，选择素似乎会增加。微粒和选择素在溃疡性结肠炎和克罗恩病等炎症性肠道疾病中还没有得到仔细的研究。这项研究将检查(1)炎症性肠病患者血液中的微粒和选择素是否增加，以及(2)炎症性肠病患者血液中的微粒和选择素是否比病情较轻的人更多。如果是这样的话，减少血液中的微粒或选择素的治疗可能对炎症性肠病有利。我们将邀请60名溃疡性结肠炎患者(20名轻度患者，20名中度患者，20名重度活动患者)，60名克罗恩病患者(20名轻度患者，20名中度患者，20名重度疾病活动患者)，以及30名在胃肠道诊所没有炎症性疾病、感染或活动性癌症的患者参加。每个受试者将被要求填写一份人口统计表，如果他们有炎症性肠病，则填写一份疾病活动表。然后，我们将抽取6毫升血液(约1茶匙)，用于测量微粒和选择素。如果他们要抽血进行临床测试，我们会同时进行，这样他们便无须抽血两次。他们对这项研究的参与将是完整的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Microparticles are small pieces of cells that are released from white blood cells, platelets, and the cells that line blood vessels (endothelial cells) during inflammation. Microparticles have been found to be increased in people with multiple sclerosis, heart attacks, bacterial infections in the blood, and several other diseases in which inflammation is important. Microparticles appear to help white blood cells and platelets stick to the walls of blood vessels in areas of inflammation. This can result in increased inflammation and blood clotting. Selectins are adhesion molecules that help microparticles and blood cells stick to blood vessel walls. Selectins appear to be increased in some inflammatory diseases. Microparticles and selectins have not been carefully studied in inflammatory bowel diseases like ulcerative colitis and Crohns disease. This study will examine (1) whether people with inflammatory bowel disease have increased microparticles and selectins in their blood and (2) whether people who are more sick with inflammatory bowel disease have more microparticles and selectins in their blood than people who are less sick. If this is the case, treatments that reduce microparticles or selectins in the blood might be beneficial in inflammatory bowel diseases. We will ask 60 patients with ulcerative colitis (20 with mild, 20 with moderate, and 20 with severe disease activity), 60 patients with Crohns disease (20 with mild, 20 with moderate, and 20 with severe disease activity), and 30 patients at the GI clinic with no inflammatory disease, infection, or active cancer to participate. Each subject will be asked to fill out a demographics form, and a disease activity form if they have inflammatory bowel disease. We will then draw 6 mL of blood (about 1 teaspoon) for the measurement of microparticles and selectins. If they are going to have a blood draw for clinical testing, we will do it at the same time, so that they do not have to have two blood draws. Their participation in the study will then be complete.