Clinical Research in Digestive Diseases (CRDD) Training Program

摘要 本申请旨在更新消化系统疾病临床研究（CRDD）培训 程序（T32 DK 062708）。该培训方案自2003年以来一直得到资助， 优秀的记录准备医生，科学家在临床成功的职业生涯 research.在过去的19年里（2003-2022），我们的22个项目毕业生中有81%达到了 研究密集型（45%）或研究相关（36%）学术职位。在此期间，我们的22 毕业生获得了21个学术职位，15个K-当量（职业发展） 奖项，和25 R，U，或同等的高级研究奖。该方案的目标是 通过提供以下服务，培养未来在GI和肝病临床研究方面的独立研究者 选定的研究员具有：（1）设计和执行临床研究的核心技能;以及（2） 在我们世界一流的核心教师的指导下，结构化，指导性的研究经验。 本次申请拟资助博士后研究员共3人，其中1人已被录取 每年进行为期3年的培训，从GI奖学金的第一个临床年开始 训练该培训计划的基本原理是：（1）胃肠道和肝脏疾病 是发病和死亡的主要原因，流行病学不断发展，负担日益加重; (2)消化系统疾病是由需要多学科的复杂过程推动的。 方法;（3）该领域面临着各种调查人员的威胁，他们致力于 研究消化系统疾病的职业，特别是在COVID-19大流行的压力因素之后。 我们的培训计划的设计包括（1）招聘有才华的、多样化的候选人 致力于研究事业;（2）沉浸式，个性化的培训计划 （3）为独立成功的课程毕业生做好精心准备 careers.所有学员都参加了一个有指导的研究经验，由一个研究支持， 咨询委员会。学员是在一个单独的临床研究比赛中选出的，当他们 申请临床培训。所有受训人员均获得临床研究方法硕士学位 在他们的研究金的第二年，这是研究培训的第一年。核心 课程包括研究设计和统计，负责任的研究行为的培训， 可复制的研究实践，沟通技巧，赠款写作和职业发展。 自上次更新以来增加的新研究领域包括：（1）机器学习和深度学习 学习方法;（2）数据科学和精准医学;（3）自适应和平台试验 设计;（4）健康公平。根据我们现有研究员的反馈和许多成功的 校友们，我们正在不断改进这个成功的T32培训计划。

ABSTRACT This application aims to renew the Clinical Research in Digestive Diseases (CRDD) Training Program (T32 DK062708). This training program, continuously funded since 2003, has an excellent track record of preparing physician-scientists for successful careers in clinical research. In the past 19 years (2003-2022), 81% of our 22 program graduates have attained research-intensive (45%) or research-related (36%) academic positions. During this time, our 22 graduates have earned 21 academic appointments, 15 K-equivalent (career development) awards, and 25 R, U, or equivalent senior research awards. The objective of the program is to develop future independent investigators in GI and hepatology clinical research by providing selected fellows with: (1) core skills in the design and execution of clinical research; and (2) a structured, mentored research experience under the guidance of our world-class Core Faculty. This application proposes to support a total of 3 postdoctoral research fellows with one enrolled each year for a 3-year training period, beginning after their first clinical year of GI fellowship training. The rationale for this training program is that (1) gastrointestinal and hepatic diseases are major causes of morbidity and mortality with evolving epidemiology and increasing burden; (2) digestive diseases are propelled by complex processes in need of multidisciplinary approaches; and (3) the field faces a threatened pipeline of diverse investigators committed to careers studying digestive diseases, particularly after the stressors of the COVID-19 pandemic. The design of our training program includes (1) recruitment of talented, diverse candidates committed to careers in research; (2) an immersive, individualized training plan for program trainees; and (3) deliberate preparation of program graduates for independently successful careers. All trainees participate in a mentored research experience, supported by a research advisory committee. Trainees are selected in a separate clinical research match when they apply for clinical training. All trainees acquire a master's degree in clinical research methods during their second year of fellowship, which is the first year of research training. The core curriculum includes research design and statistics, training in responsible research conduct and reproducible research practices, communication skills, grant writing, and career development. New research areas added since the last renewal include: (1) machine learning and deep learning methods; (2) data science and precision medicine; (3) adaptive and platform trial design; and (4) health equity. Based on feedback from our current fellows and many successful alumni, we are continuously improving this successful T32 training program.