STUDY OF ENDOTHELIAL DYSFUNCTION AND INSULIN RESISTANCE IN HIV-INFECTED PATIENTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目前，对于在接受高效抗逆转录病毒治疗(HAART)的HIV感染患者中观察到的心血管风险增加、胰岛素抵抗和体脂变化的总体临床相关性存在争议。有必要了解HAART中内皮功能障碍和胰岛素抵抗的演变。这项研究将量化多达60名接受HAART的HIV感染男性和女性的内皮功能、胰岛素抵抗、脂肪分布和心血管疾病风险终点的纵向变化。这些参数将使用2小时的臂动脉反应性测试，即血管/内皮功能的血清生物标记物来测量。口服葡萄糖耐量试验和双能X射线吸收法(DEXA)。参与者将通过GCRC和心血管研究实验室进行这项测试。这些测试将在注册时(基线)进行，并每年进行一次为期3年的跟踪。预计患者的内皮功能将在3年内至少下降5%。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently there is debate as to the overall clinical relevance of the increased cardiovascular risk, insulin resistance, and body fat changes observed in HIV-infected patients on highly active antiretroviral therapy (HAART). There is a great need to understand the evolution of endothelial dysfunction and insulin resistance in HAART. This study will quantify longitudinal changes in endotheilia funciton, insulin resistance, fat distribution, and cardiovascular disease risk endpoints in up to 60 HIV-infected men and women receiving HAART. These parameters will be measured using brachial artery reactivity testing, serum biomarkers of vascular/endothelial function, 2-hr. oral glucose tolerance testing, and dual energy x-ray absorptiometry (whole-body DEXA). Participants will undergo this testing through the GCRC and the Cardiovascular Reseaach Lab. These tests will occur upon enrollment (baseline) and at yearly intervals for 3 years of follow-up. It is expected that endothelial function in patients will decline by at least 5% over 3 years.