STUDY OF ENDOTHELIAL DYSFUNCTION AND INSULIN RESISTANCE IN HIV-INFECTED PATIENTS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently there is debate as to the overall clinical relevance of the increased cardiovascular risk, insulin resistance, and body fat changes observed in HIV-infected patients on highly active antiretroviral therapy (HAART). There is a great need to understand the evolution of endothelial dysfunction and insulin resistance in HAART. This study will quantify longitudinal changes in endotheilia funciton, insulin resistance, fat distribution, and cardiovascular disease risk endpoints in up to 60 HIV-infected men and women receiving HAART. These parameters will be measured using brachial artery reactivity testing, serum biomarkers of vascular/endothelial function, 2-hr. oral glucose tolerance testing, and dual energy x-ray absorptiometry (whole-body DEXA). Participants will undergo this testing through the GCRC and the Cardiovascular Reseaach Lab. These tests will occur upon enrollment (baseline) and at yearly intervals for 3 years of follow-up. It is expected that endothelial function in patients will decline by at least 5% over 3 years.