PACTG P1055, VERSION 10

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。P1055是一项多中心、非治疗、观察性研究，旨在更好地了解艾滋病毒对围产期感染艾滋病毒的儿童和青少年队列中精神症状发展的影响，并与人口统计学上匹配的对照受试者队列进行比较。这项研究的意义在于它专注于暴露在嗜神经病毒和治疗方案中的潜在高危样本，这些治疗方案改变了对大脑的渗透。在本研究中，控制组的受试者将按性别和年龄层次与艾滋病毒感染者组的受试者进行频率匹配(即与6岁至12岁的女性、6岁至12岁的男性、12岁至18岁的女性以及12岁至18岁的男性的比例相同)。在这项研究中，受试者将不接受治疗；受试者及其父母/主要照顾者将回答一系列问卷/措施，这些问卷/措施将用于评估当前精神症状和障碍的患病率和严重程度，并评估随着时间的推移而发生的变化。这项研究分为两个部分，即当前精神障碍和症状的流行率和严重程度(第一次研究访问时的精神健康部分)和症状学随时间的变化(第二次和第三次研究访问时的后续部分)。此外，一组围产期感染艾滋病毒的受试者和对照受试者(每组100-120名受试者)及其父母/主要照顾者将以半结构化精神病学访谈的形式接受额外措施，以进一步确定感染艾滋病毒的儿童或青少年和对照受试者的精神症状的不同频率，并确定长期后续研究的可行性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. P1055 is a multicenter, non-treatment, observational study designed to better understand the impact of HIV on the development of psychiatric symptomatology in a cohort of perinatally HIV-infected children and adolescents, when compared to a cohort of demographically matched control subjects. The significance of this study rests in its focus on a potentially high-risk sample exposed to a neurotropic virus and therapeutic regimens with altered penetration into the brain. For the purposes of this study, subjects in the control group will be frequency matched (i.e., will be matched with the same percentage of 6 to < 12 year-old females, 6 to < 12 year-old males, > 12 to < 18 year-old females, and > 12 to < 18 year-old males) to those in the HIV-infected group by gender and age strata. Subjects will not receive treatment in this study; subjects and their parents/primary caregivers will respond to a series of questionnaires/measures which will be used to assess the prevalence and severity of current psychiatric symptoms and disorders and to assess changes over time. The study is divided into two components, the prevalence and severity of current psychiatric disorders and symptoms (Mental Health Component at the first study visit) and changes in symptomatology over time (Follow-Up Component at the second and third study visits). In addition, a subset of perinatally HIV-infected and control subjects (100-120 subjects from each group) and their parents/primary caregivers will receive additional measures, in the form of semi-structured psychiatric interviews, to further identify the differential frequency of psychiatric symptoms in HIV-infected children or adolescents and control subjects and to establish the feasibility of a long-term follow-up study.