MECHANISMS OF BONE TURNOVER IN TYPE 1 DIABETES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。观察表明，控制不佳的1型糖尿病儿童和青少年有骨量下降的风险。最近，通过双能X射线骨密度仪(DXA)测量的腰椎骨密度降低已在1型糖尿病青少年中被报道。我们的研究小组观察到，与长期参考人群相比，我们的研究小组在青少年1型糖尿病横断面和纵向研究中观察到较低的胫骨小梁vBMD(p=.01)、腰椎和全身骨矿含量和密度(p0.05)以及全身骨矿含量获取(p0.02)。本研究致力于以下特定目的：比较患有1型糖尿病的青少年、女孩和匹配的对照组(n=6，年龄和成熟度配对)的骨代谢。从这些对象收集的数据将用于加强根据GCRC第0319号议定书收集的数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Observations suggest that children and adolescents with poorly controlled Type 1 diabetes are at risk for decreased bone mass. Most recently, reduced lumbar BMD measured by dual energy x-ray absorptiometry (DXA) has been reported in Type 1 diabetic adolescents. Our research group has observed lower tibia trabecular vBMD (p=.01), lumbar spine and whole body bone mineral content and density (p0.05), and whole body bone mineral content acquisition (p0.02) in both cross-sectional and longitudinal studies of adolescents with Type 1 diabetes when compared to a secular reference population. This study addresses the following specific aim: To compare bone metabolism in adolescents girls with Type 1 diabetes mellitus and matched controls (n=6 age and maturation-matched pairs). Data collected from these subjects will be used to strengthen data collected under GCRC Protocol # 0319.