Cerebro/peripheral vascular function in cognition

认知中的脑/周围血管功能

• 批准号: 6829278
• 负责人: DAVID J MOSER
• 金额: $ 6.05万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6829278
• 关键词: aging; atherosclerosis; cardiovascular function; cerebrovascular system; clinical research; cognition; human old age (65+); human subject; magnetic resonance imaging; memory; peripheral blood vessel; positron emission tomography

DESCRIPTION (provided by applicant): This proposal is submitted in response to PAR-03-056: NIA Pilot Research Grant Program, Research Objective #2: Cardiovascular and Cerebrovascular Aging: Behavioral, clinical, social, cellular, and molecular studies of cardiovascular and cerebrovascular aging. The PI (David J. Moser, Ph.D.) is in his first year of a career development award from NIA (1 K23 AG020649-01A1; "Aging, Vascular Disease and Cognition") and is conducting a longitudinal study on forearm blood vessel function and cognition in elderly patients with atherosclerosis. That ongoing study is based on preliminary data showing a strong relationship between forearm blood vessel function and cognition in these patients. For reasons discussed in detail in the body of this proposal, it is surmised that blood vessel function may serve as an indicator of total atherosclerotic risk factor burden and, because it is significantly associated with level of cognitive function, it is hypothesized that it will also be found to be associated with subsequent vascular-related cognitive decline. With additional research, this could eventually lead to the use of blood vessel function measures in the early identification of those individuals at greatest risk for vascular cognitive decline and dementia. What is lacking in the Prs current K23 project is a mechanism by which the relationship between forearm blood vessel function and cerebrovascular function can be explored. It is assumed that the relationship between forearm blood vessel function and cognition demonstrated by the preliminary data is the result of compromised cerebrovascular function but this has never been studied. If funded, the proposed pilot study will enable our research team to conduct PET imaging on 20 elderly subjects enrolled in the Prs K23 project, allowing for an unprecedented examination of the relationships among forearm blood flow, cerebral blood flow, cerebrovascular reserve, and cognition in the elderly. The proposed research is expected to yield publishable results and will also provide valuable pilot data for larger scale (e.g. R01) grant applications.

描述（由申请人提供）：本提案是为了响应PAR-03-056：NIA试点研究资助计划，研究目标#2：心血管和脑血管衰老：心血管和脑血管衰老的行为、临床、社会、细胞和分子研究而提交的。PI（大卫J. Moser，博士）他是NIA职业发展奖的第一年（1 K23 AG 020649 - 01 A1;“衰老、血管疾病和认知”），正在进行一项关于动脉粥样硬化老年患者前臂血管功能和认知的纵向研究。这项正在进行的研究是基于初步数据，这些数据显示了这些患者前臂血管功能和认知之间的密切关系。由于在本提案正文中详细讨论的原因，推测血管功能可作为总动脉粥样硬化风险因素负荷的指标，并且由于其与认知功能水平显著相关，因此假设其也将与随后的血管相关认知下降相关。通过进一步的研究，这可能最终导致使用血管功能测量来早期识别那些血管性认知能力下降和痴呆风险最大的个体。目前的Prs K23项目缺乏的是一种机制，通过这种机制可以探索前臂血管功能和脑血管功能之间的关系。据推测，前臂血管功能和认知能力之间的关系，初步数据表明，是脑血管功能受损的结果，但这从来没有被研究过。如果获得资助，拟议的试点研究将使我们的研究团队能够对参加Prs K23项目的20名老年受试者进行PET成像，从而对老年人前臂血流、脑血流、脑血管储备和认知之间的关系进行前所未有的检查。预计拟议的研究将产生可验证的结果，并将为更大规模（例如R 01）的赠款申请提供有价值的试点数据。