DIETARY ANTIOXIDANT INFLUENCE ON MARKERS OF ATHEROSCLEROSIS AND OXIDATIVE STRESS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。许多观察和实验研究表明，动脉粥样硬化的公认危险因素促进了血管系统中的炎症氧化环境，这有助于内皮中病理变化的演变。现在有相当多的证据表明，内皮功能障碍既先于动脉粥样硬化，又加速动脉粥样硬化。因此，抗氧化剂营养素，包括维生素C、维生素E、β-胡萝卜素、硒和锌，可能有助于减少内皮功能障碍并降低心血管事件的发生率。然而，以前在临床试验中使用抗氧化剂补充剂产生了令人失望和有争议的结果。膳食抗氧化剂维生素的使用在美国继续增长。本研究的目的是比较最广泛使用的补充和膳食抗氧化剂对内皮异常的不同标志物的影响。由于内皮功能障碍是动脉粥样硬化形成的关键潜在因素，内皮依赖性血管运动和循环内皮活性标志物（炎症标志物）的测试可以提供一种快速可靠的方法，以低成本评估抗氧化程序的临床结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A number of observational and experimental studies have shown that the recognized risk factors for atherosclerosis promote an inflammatory oxidative environment in the vasculature that is conducive to the evolution of pathologic changes in the endothelium. Considerable evidence now exists that endothelial dysfunction both precedes and accelerates atherosclerosis. Antioxidants nutrients, including vitamin C, vitamin E, beta-carotene, selenium, and zinc are therefore likely to contribute to a decrease of endothelial dysfunction and diminish the incidence of cardiovascular events. However, the previous use of antioxidant supplements in clinical trials has yielded disappointing and controversial results. The use of dietary antioxidant vitamins continues to grow in the US. The aim of this study is to contrast the effects of the most widely used supplemental and dietary antioxidants on different markers of endothelial abnormalities. As endothelial dysfunction is a key underlying factor in atherogenesis, tests of endothelium dependent vasomotion and on circulating markers of endothelial activity (inflammatory markers) may provide a rapid and reliable methodology to assess the clinical outcome of antioxidant procedures at low cost.