FAMILY STUDIES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究的目的是调查受影响的先证者及其家庭成员中糖尿病和心血管疾病(CVD)风险的决定因素。我们认为，目前最关键的研究领域是揭示糖尿病和肥胖症的遗传易感性的作用，以及它与不断变化的行为危险因素流行病学的相互作用。初级数据收集数据将在先证者家中进行，并通过儿童权利中心在核心实验室进行处理。此外，当一个家庭想要参与，但不想让研究人员来到他们的家中(1级)时，将使用CRC。CRC还将用于对以前在家中或CRC(2级)中看到的参与者的子集进行更详细的测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate the determinants of diabetes and cardiovascular disease (CVD) risk in affected probands and their family members. We believe that the most critical area of research at this point in time is to unravel the role of genetic susceptibility to diabetes and obesity, and its interaction with the changing epidemiology of behavioral risk factors. The primary data collection data will be done in the proband's home and processed in the CORE laboratory through the CRC. Also, the CRC will be used for those instances when a family wants to participate but does not want to have the research staff come to their home (level 1). The CRC will also be used for a more detailed exam with a sub-set of participants who were seen previously in their home or the CRC (level 2).