T1DGC THE TYPE 1 DIABETES GENETICS CONSORTIUM NORTH AMERICAN REGIONAL NETWORK

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The University of Chicago will establish a recruitment site for an NIH-funded collaboration, the "Type 1 Diabetes Genetics Consortium" (T1DGC). The goal of the Consortium is to organize international efforts to identify genes that determine an individual's risk of type 1 diabetes. Progress towards this goal, worldwide, has been limited by a lack of sufficient clinical and genetic resources. The power of larger collections of families to map type 1 diabetes genes has been demonstrated in a pilot study. The creation of a resource base of well-characterized families from multiple ethnic groups will facilitate the localization and characterization of type 1 diabetes genes that determine disease risk. Statistical genetic analyses will be performed on appropriately powered data sets to identify regions linked to type 1 diabetes and determine how these linked regions act and potentially interact. Building upon these Consortium resources, members and collaborators of the Consortium will undertake positional cloning to identify individual genes that determine susceptibility or protection.