CHICAGO MINORITY TYPE I DIABETES REGISTRY

糖尿病被广泛认为是非洲人的主要健康问题。 美国人和西班牙裔美国人在美国相对较少的关注， 儿童糖尿病是这个问题的一个组成部分。 虽然胰岛素依赖型糖尿病（IDDM）的风险是 一般认为，少数民族儿童和青少年的 在非西班牙裔白人中，有证据表明， 发病率和死亡率很可能会增加。 1型糖尿病是一种 儿童重要疾病由于其相对流行，成本 终身治疗，以及并发症和 过早死亡 关于描述性的知识库 美国黑人和城市西班牙裔人中胰岛素依赖型糖尿病的流行病学 国家仍然非常脆弱，在很大程度上是因为没有 试图组织对人群中多种风险因素的研究， 足够大的中心。 因此，我们提出了一个基于人口的 芝加哥黑人和拉丁裔儿童糖尿病患者登记处。 的 芝加哥大都会区是大量非洲裔美国人的家园 和西班牙裔，以及其他移民群体，并提供了一个独特的 有机会研究这些少数民族糖尿病发病率的模式 人口。 只有掌握了基本的发病率数据， 推迟或预防少数群体儿童的并发症， 这种疾病的社会成本将变得可行。 本登记研究的数据将允许评价以下方面的差异： 在黑人和西班牙裔中的胰岛素依赖型糖尿病风险。 具体而言，建议 研究将：1）回顾性确定IDDM的发病率， 1985年至1990年，以及前瞻性至1995年，在黑人和西班牙裔儿童中 在伊利诺伊州芝加哥市，未满18岁; 2）检查 按社会经济地位分列的族裔群体内的发病率; 3）确定 胰岛素依赖型糖尿病的发病率因性别、年龄或季节而异。 年，以及发病率是否增加，减少，或 在研究期间保持稳定;以及4）确定 西班牙裔人群中胰岛素依赖型糖尿病的发病率随地理分布而变化。 起源的位置和存在的遗传混合物的程度。 一旦登记人群确定，将进行进一步研究， 疾病的自然史，并评估护理质量， 少数民族人口。 具体的研究问题将解决某些 少数民族胰岛素依赖型糖尿病的遗传相关性，家族性胰岛素依赖型糖尿病的模式， 胰岛素依赖型糖尿病的聚集以及该疾病对儿童的社会和财政影响 少数民族家庭。

Diabetes is widely recognized as a major health concern among African Americans and Hispanics in the U.S. Relatively little attention has been directed to childhood diabetes as a component of this problem, however. Although the risk of insulin-dependent diabetes mellitus (IDDM) is generally thought to be lower among minority children and adolescents than among non-Hispanic whites, there is evidence that the associated morbidity and mortality may well be increased. Type I diabetes is an important disease of childhood due to its relative prevalence, the costs of lifelong treatment, and the long term risks for complications and premature mortality. The knowledge base regarding the descriptive epidemiology of IDDM among blacks and urban Hispanics in the United States remains very weak, in large measure because there have been no attempts to organize studies on multiple risk factors in a population center of sufficient size. Therefore we propose a population-based registry of black and Latino childhood diabetes patients in Chicago. The Chicago metropolitan area is home to large numbers of African-Americans and Hispanics, as well as other immigrant groups, and provides a unique opportunity to study the patterns of diabetes incidence in these minority populations. It is only with basic incidence data in hand that attempts to delay or prevent complications among minority children and to address the social costs of the disease, will become feasible. The data from this registry will allow the evaluation of differences in risk for IDDM in blacks and Hispanics. Specifically, the proposed research will: 1) determine the incidence of IDDM retrospectively from 1985 to 1990, and prospectively to 1995, in black and Hispanic children under the age of 18 in the city of Chicago, Illinois; 2) examine incidence within ethnic groups by socioeconomic status; 3) determine if the incidence of IDDM varies by sex, by age, or by the season of the year, and whether the incidence rate has increased, decreased, or has remained stable over the study period; and 4) determine whether the incidence of IDDM among Hispanic populations varies with geographic location of origin and with the degree of genetic admixture present. Once the registry population is established, further studies will assess the natural history of the disease and evaluate the quality of care for minority populations. Specific research questions will address certain genetic associations with IDDM in minority patients, patterns of familial aggregation of IDDM and the social and financial impact of the disease on minority families.