EVAL OF PLANT STEROL ESTER & PLACEBO ON LOW-DENSITY LIPOPROTEIN CONCENTRATIONS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。降低胆固醇已被证明可以减少心脏病发作和与心脏病有关的死亡。在美国有很多降低胆固醇的药物。有些药物会被人体吸收，并与其他药物产生相互作用。然而，有些药物可以在不被人体吸收的情况下降低胆固醇。最近，美汁源公司在美国推出了降低胆固醇的橙汁。这项研究的目的是为了更好地了解降胆固醇药物Welchol¿的效果，这种药物不会被人体吸收，与降胆固醇橙汁（美汁源心脏智慧）结合使用对高胆固醇男性和女性的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lowering cholesterol has been shown to reduce heart attacks and deaths related to heart disease. There are many medications available in the U.S. to lower cholesterol. Some medications are absorbed into the body and cause drug interactions with other medications. However, some medications lower cholesterol without being absorbed into the body. Recently, orange juice that lowers cholesterol has been marketed in the U.S. by the Minute Maid Corporation. The goal of this study is to better understand the effects of the cholesterol-lowering drug Welchol¿, which is not absorbed into the body, in combination with cholesterol-lowering orange juice (Minute Maid Heart Wise¿) in men and women with high cholesterol.