EFFECTS OF MEAL OCCASION & PLANT STEROL MULTIPLE CVD RF IN MOD HYPERCHOLESTEROL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目标：为了评估对多种心血管疾病（CVD）风险因素的影响，包括血浆脂质，脂蛋白，载脂蛋白，促炎标志物和脂肪酸谱，当植物甾醇补充的迷你饮料每天在早餐或晚餐时以不同剂量食用一次。 假设：在中度高胆固醇血症（LDL-胆固醇110 mg/dL）的健康受试者中，每天一次与早餐或晚餐一起饮用植物甾醇补充（2 g/d）迷你饮料将使总胆固醇和LDL-胆固醇降低至少~5%，并有益地影响血脂、脂蛋白、载脂蛋白、促炎标志物和脂肪酸谱。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Goal: To evaluate the effects on multiple cardiovascular disease (CVD) risk factors, including plasma lipids, lipoproteins, apolipoproteins, pro-inflammatory markers and the fatty acid profile, when a plant-sterol supplemented mini-drink is consumed once a day at either breakfast or dinner at varying doses. Hypothesis: Consumption of a plant sterol supplemented (2 g/d) mini-drink once a day with breakfast or dinner will decrease total and LDL-cholesterol by at least ~5% and beneficially affect plasma lipids, lipoproteins, apolipoproteins, pro-inflammatory markers, and the fatty acid profile in healthy subjects with moderate hypercholesterolemia (LDL-cholesterol 110 mg/dL).