CORTISOL METABOLISM AND CENTRAL ADIPOSITY AFTER MENOPAUSE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。有证据表明，腹部脂肪与患冠状动脉疾病(一种常见的心脏病)和2型糖尿病(也称为成人糖尿病)的风险增加有关。绝经后，女性的腹部往往会增加脂肪。以前的研究表明，脂肪含量较高的女性会产生更多的压力荷尔蒙，称为皮质醇。有证据表明，当腹部脂肪细胞被从体内取出(组织活检样本)时，它们具有一种酶，可以将皮质醇(激素的非活性形式)转化为皮质醇(激素的活性形式)。我们研究的第一个目标是测量腹部脂肪细胞在脂肪组织在体内时将皮质醇转化为皮质醇的能力。我们研究的第二个目标是比较肥胖和正常体重的绝经后妇女如何代谢皮质醇。我们想要了解你全身和腹部脂肪将皮质醇转化为皮质醇的能力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is evidence that abdominal fat is associated with increased risk for coronary artery disease (a common type of heart disease) and Type 2 diabetes mellitus (also known as 'adult onset diabetes'). After menopause women tend to gain fat in the abdominal region. Previous studies show that women with larger amounts of fat make more of a stress hormone called cortisol. There is evidence that when abdominal fat cells are taken out of the body (tissue biopsy samples), they have an enzyme that can convert cortisone (the inactive form of the hormone) to cortisol (the active form of the hormone). The first goal of our study is to measure the ability of abdominal fat cells to convert cortisone to cortisol while the fat tissue is in your body. The second goal of our study is to compare how obese and normal weight postmenopausal women metabolize cortisol. We want to find out the ability of your whole body as well as your abdominal fat to convert cortisone to cortisol.