COGNITIVE EFFECTS OF DOPAMINE D2 RECEPTOR STIMULATION

多巴胺 D2 受体刺激的认知效应

• 批准号: 7377886
• 负责人: RANDALL CHARLES O'REILLY
• 金额: $ 1.11万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377886
• 关键词: COGNITIVE; EFFECTS; DOPAMINE; D2; RECEPTOR

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The neurotransmitter dopamine (DA) is importantly involved in many cognitive processes , but it is still not clear exactly how. Ongoing studies with Parkinson's patients and computational modeling of network level brain interactions suggest that the level of D2 receptor stimulation in the basal ganglia controls the threshold for initiating a motor response and for updating working memory. We will test this hypothesis more directly in young healthy individuals by administering cabergoline (D2 agonist), haloperidol (D2 antagonist), and placebo. We predict that cabergoline lowers the threshold for initiating motor responses and updating working memory, whereas haloperidol raises this threshold, relative to placebo.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。神经递质多巴胺(DA)在许多认知过程中起着重要的作用，但目前还不清楚具体是如何参与的。对帕金森氏症患者正在进行的研究和对网络水平大脑相互作用的计算建模表明，基底节中D2受体刺激的水平控制着启动运动反应和更新工作记忆的阈值。我们将通过给予卡麦角林(D2激动剂)、氟哌啶醇(D2拮抗剂)和安慰剂，在年轻的健康个体中更直接地检验这一假设。我们预测，相对于安慰剂，卡麦角林降低了启动运动反应和更新工作记忆的阈值，而氟哌啶醇则提高了这一阈值。