COGNITIVE EFFECTS OF DOPAMINE D2 RECEPTOR STIMULATION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。神经递质多巴胺（DA）在许多认知过程中起着重要作用，但目前尚不清楚具体是如何参与的。正在进行的帕金森氏症患者的研究和网络水平大脑相互作用的计算模型表明，基底神经节中D2受体的刺激水平控制着启动运动反应和更新工作记忆的阈值。我们将通过使用卡麦角林（D2激动剂）、氟哌啶醇（D2拮抗剂）和安慰剂在年轻健康个体中更直接地验证这一假设。我们预测卡麦角林降低了启动运动反应和更新工作记忆的阈值，而氟哌啶醇相对于安慰剂提高了这个阈值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The neurotransmitter dopamine (DA) is importantly involved in many cognitive processes , but it is still not clear exactly how. Ongoing studies with Parkinson's patients and computational modeling of network level brain interactions suggest that the level of D2 receptor stimulation in the basal ganglia controls the threshold for initiating a motor response and for updating working memory. We will test this hypothesis more directly in young healthy individuals by administering cabergoline (D2 agonist), haloperidol (D2 antagonist), and placebo. We predict that cabergoline lowers the threshold for initiating motor responses and updating working memory, whereas haloperidol raises this threshold, relative to placebo.