Core 3: Computational (290-307)

核心 3：计算 (290-307)

• 批准号: 7828026
• 负责人: RANDALL CHARLES O'REILLY
• 金额: $ 23.54万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7828026
• 关键词: Address; Brain; Characteristics; Child Development; Computer Analysis; Computer Simulation; Development; Disease; Emotional; Emotions; Ethics; Faculty; Functional disorder; Goals; Human Resources; Intervention; Investigation; Learning; Lesion; Link; Mental disorders; Modeling; Neuroanatomy; Neurobiology; Postdoctoral Fellow; Process; System; Thinking; Training; cognitive control; computer infrastructure; design; executive function; insight; member; psychologic; research study

The computational modeling core is designed to support the development of biologically plausible computational models across the range of projects proposed in the center. Various existing models have been developed for the experimental tasks employed across all of the proposed projects. This includes models of cognitive control (Project 1), learning (Project 2), emotion (Project 3), dompainergic infulences on executive funciton (Project 4) and child development (Project 5). Because these models are biologically inspired they consider both neurobiological and psychological constraints on processing. The development of computational models provides an important way of synthesizing experimental results in a mechanistic fashion, and generating predictions for further experimental studies. These models will be used in parallel with empirical investigations so that theycan inform each other. Because of these characteristics, the computational core explicitly addresses a center goal of linking levels of analysis (computational, psychological, and neurobiological) in our understanding of executive function. The personnel associated with the computational core will provide both the faculty and post-doctoral expertise with regards to the creation, implementation and evaulation of comptuational models for all projects within the center. In addition, it will provide the computational infrastructure for those investigations as well as training materials and training opportunity for center members. Computational models of executive function can provide insights into psychiatric disorders in numerous ways. For example, models can be "lesioned" or altered in ways that are impossible to do experimentally for either ethical or practical reasons. As such, they can provide insights into the mechanisms that support disordered thoughts or emotional processes. Furthermore, they may provide insights into mechanisms or interventions that might be effective in overcoming such disorders. This is especially true of the models proposed for this center, which are explicitly linked to the neuroanatomy and functioning of brain systems as well as the psychological processes that support executive function.

计算建模核心旨在支持生物学上合理的开发 该中心提出的一系列项目的计算模型。现有的各种型号都有 是为所有拟议项目中采用的实验任务而开发的。这包括 认知控制模型（项目 1）、学习模型（项目 2）、情绪模型（项目 3）、多胺能影响 执行功能（项目 4）和儿童发展（项目 5）。因为这些模型是生物学上的 受到启发，他们考虑了神经生物学和心理学对处理的限制。发展历程 计算模型的建立提供了一种在机械中综合实验结果的重要方法 时尚，并为进一步的实验研究生成预测。这些模型将并行使用 通过实证调查，以便他们可以互相告知。由于这些特点， 计算核心明确解决了链接分析级别（计算、 心理学和神经生物学）在我们对执行功能的理解中。 与计算核心相关的人员将提供教职人员和博士后 为所有项目创建、实施和评估计算模型的专业知识 中心内。此外，它还将为这些调查提供计算基础设施 作为中心成员的培训材料和培训机会。 执行功能的计算模型可以提供对许多精神疾病的见解 方式。例如，模型可能会被“损害”或以不可能通过实验进行的方式进行改变。 无论是道德原因还是实际原因。因此，他们可以提供对支持机制的见解 混乱的思想或情绪过程。此外，它们可以提供对机制或 可能有效克服此类疾病的干预措施。对于模型来说尤其如此 为该中心提出建议，其与神经解剖学和大脑系统的功能明确相关 以及支持执行功能的心理过程。